{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:37:10Z","timestamp":1790285830240,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Vonoprazan, a potassium\u2010competitive acid blocker, is expected to improve the healing of endoscopic submucosal dissection (\n ESD<\/jats:styled-content>\n )\u2010induced gastric ulcers compared with proton pump inhibitors (\n PPI<\/jats:styled-content>\n s).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To compare the healing status of\n ESD<\/jats:styled-content>\n \u2010induced gastric ulcers and the incidence of post\u2010\n ESD<\/jats:styled-content>\n bleeding between subjects treated with vonoprazan for 5 weeks and those treated with\n PPI<\/jats:styled-content>\n s for 8 weeks.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients in the vonoprazan group (\n n<\/jats:italic>\n = 75) were prospectively enrolled, whereas patients in the\n PPI<\/jats:styled-content>\n group (\n n<\/jats:italic>\n = 150) were selected for a 2:1 matched historical control cohort according to baseline characteristics including gastric ulcer size immediately following\n ESD<\/jats:styled-content>\n , age, sex and status of\n Helicobacter pylori<\/jats:italic>\n infection. Two controls per case of vonoprazan\u2010treated group were matched with a margin of 20% in terms of ulcer size and a margin of 5 years in terms of their age.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Although a higher number of completely healed ulcers was observed in the\n PPI<\/jats:styled-content>\n group (95\/150, 63.3%) than that in the vonoprazan group (14\/75, 18.7%;\n P<\/jats:italic>\n < 0.001), the ulcer size reduction rates, which were 96.0 \u00b1 6.7% in the vonoprazan group and 94.7 \u00b1 11.6% in the\n PPI<\/jats:styled-content>\n group, were not significantly different (\n P<\/jats:italic>\n = 0.373). The post\u2010\n ESD<\/jats:styled-content>\n bleeding incidence in the vonoprazan group (1\/75, 1.3%) was less than that in the\n PPI<\/jats:styled-content>\n group (15\/150, 10.0%;\n P<\/jats:italic>\n = 0.01). The factors affecting post\u2010\n ESD<\/jats:styled-content>\n bleeding incidence were the type of acid secretion inhibitor (\n P<\/jats:italic>\n = 0.016) and use of an anti\u2010thrombotic agent (\n P<\/jats:italic>\n = 0.014).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Vonoprazan significantly reduced post\u2010endoscopic submucosal dissection bleeding compared with\n PPI<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.13747","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T04:04:05Z","timestamp":1469678645000},"page":"583-591","source":"Crossref","is-referenced-by-count":58,"title":["Vonoprazan prevents bleeding from endoscopic submucosal dissection\u2010induced gastric ulcers"],"prefix":"10.1111","volume":"44","author":[{"given":"T.","family":"Kagawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Kagawa Prefectural Central Hospital Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Iwamuro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"},{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kagawa Prefectural Central Hospital Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kagawa Prefectural Central Hospital Takamatsu 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