{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:18:21Z","timestamp":1791519501690,"version":"4.3.4"},"reference-count":163,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1 TR000125"],"award-info":[{"award-number":["TL1 TR000125"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000127"],"award-info":[{"award-number":["UL1 TR000127"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A total proctocolectomy followed by ileal pouch\u2010anal anastomosis is a potentially curative surgery for ulcerative colitis or familial adenomatous polyposis. About 5\u201335% of patients with ulcerative colitis and 0\u201311% of patients with familial adenomatous polyposis develop subsequent inflammation of the ileal pouch termed pouchitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To provide a comprehensive analysis of the research studying the possible pathogenesis of pouchitis. The goals were to identify promising areas of investigation, to help focus clinicians, researchers and patients on how to better understand and then potentially manage ileal pouchitis, and to provide avenues for future research investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review examined manuscripts from 1981 to 2015 that discussed and\/or proposed hypotheses with supportive evidence for the potential underlying pathogenic mechanism for pouchitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pathogenesis of pouchitis is not definitively understood, but various hypotheses have been proposed, including (i) recurrence of ulcerative colitis, (ii) dysbiosis of the ileal pouch microbiota, (iii) deprivation of nutritional short\u2010chain fatty acids, (iv) mucosal ischaemia and oxygen\u2010free radical injury, (v) host genetic susceptibility and (vi) immune dysregulation. However, none of these alone are able to fully explain pouchitis pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pouchitis, similar to inflammatory bowel disease, is a complex disorder that is not caused by any one single factor. More likely, pouchitis occurs through a combination of both dysregulated host inflammatory mechanisms and interaction with luminal microbiota.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13780","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T07:26:49Z","timestamp":1472023609000},"page":"817-835","source":"Crossref","is-referenced-by-count":65,"title":["Review article: the pathogenesis of pouchitis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-8680","authenticated-orcid":false,"given":"K. M.","family":"Schieffer","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Colon and Rectal Surgery College of Medicine The Pennsylvania State University Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. D.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology College of Medicine The Pennsylvania State University Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Yochum","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Colon and Rectal Surgery College of Medicine The Pennsylvania State University Hershey PA USA"},{"name":"Department of Biochemistry &amp; Molecular Biology College of Medicine The Pennsylvania State University Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"Koltun","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Colon and Rectal Surgery College of Medicine The Pennsylvania State University Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1102942"},{"key":"e_1_2_7_3_1","first-page":"16","article-title":"Step\u2010up versus top\u2010down therapy in the treatment of ulcerative colitis","volume":"3","author":"Sandborn WJ","year":"2007","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2015.04.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6130.85"},{"key":"e_1_2_7_6_1","first-page":"355","article-title":"Diagnosis and treatment of pouchitis","volume":"4","author":"Shen B","year":"2008","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10370611"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(07)02"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.9.834"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800731121"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.22.6.462"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554181"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00703959"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.10.824"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.10.1166"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199711000-00009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199805000-00006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.1.61"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(02)00191-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02235364"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61634-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6652-8"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0623-y"},{"key":"e_1_2_7_24_1","first-page":"622","article-title":"Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch\u2010anal anastomosis","volume":"211","author":"Lohmuller JL","year":"1990","journal-title":"Ann Surg"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.4.463"},{"key":"e_1_2_7_26_1","first-page":"334","article-title":"Pouchitis following restorative proctocolectomy for ulcerative colitis: incidence and therapeutic outcome","volume":"46","author":"Madiba TE","year":"2001","journal-title":"J R Coll Surg Edinb"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0041-87811999000500005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.03.020"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181b300f4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181fded4d"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00604-4"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02054692"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.10.004"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.76"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12322"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90489-3"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.012"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-006-3470-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.02993.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126758.35603.8d"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01413.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.4.574"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-2120-2"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80158-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1223-x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40778.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000212641.90477.d0"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701873206"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2010.01006.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.04.012"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2172-y"},{"key":"e_1_2_7_52_1","first-page":"26164","article-title":"Contribution of diet to the composition of the human gut microbiota","volume":"26","author":"Graf D","year":"2015","journal-title":"Microb Ecol Health Dis"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20249"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i38.6458"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6257-2"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1997.d01-1075.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i22.2740"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.3.362"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520500527482"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.6.601"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.12.1721"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0131-2"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.4.554"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwt045"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024447"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.2.243"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300695"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000027"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0737-8"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S70119"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i11.1687"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.04.003"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.7A7303.2007"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2005.00833.x"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-1-9"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701204238"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.12.003"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6187-z"},{"key":"e_1_2_7_79_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1574-6941.1991.tb01742.x","article-title":"Growth and activities of sulphate\u2010reducing bacteria in gut contents of healthy subjects and patients with ulcerative colitis","volume":"9","author":"Gibson GR","year":"2016","journal-title":"FEMS Microbiol Ecol"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0820-8"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.127"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e3dc8b"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.041"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.9.4111-4118.2001"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307649"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066934"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9200-0"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.2.312-317.1992"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0637-x"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.5.658"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21022"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181a7b77a"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04401.x"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.021"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21460"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.01.001"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.02.009"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.444s"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.781S"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00171-9"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01465.x"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12451"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.078303"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.108"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9370"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2009.01514.x"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i12.1519"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018851723920"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820115"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02148848"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20768"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91497-R"},{"key":"e_1_2_7_114_1","first-page":"168","article-title":"Severe pouchitis successfully treated with short\u2010chain fatty acids","volume":"39","author":"Hoed PT","year":"1996","journal-title":"Can J Surg"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911163212019"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554310"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.136.10.1124"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01517.x"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5842"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520152584815"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049401"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.09.016"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01727.x"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04054.x"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.764"},{"key":"e_1_2_7_126_1","first-page":"1428","article-title":"Heritability in inflammatory bowel disease: from the first twin study to genome\u2010wide association studies","volume":"21","author":"Gordon H","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606242200"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219395110"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200502153"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301957"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1086\/339432"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.549"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31823e2d18"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.3.415"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6129"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28017"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04107.x"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i46.7323"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181f22635"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2014_778"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1398.049"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.4.499"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i34.5303"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20447"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2003.09.013"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199804000-00005"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2050-6"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.01.002"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.6.894"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1444-4"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181dcb3f2"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283412fd4"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1587-6"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/823710"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.530"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182417358"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318280fcb9"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3047-0"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000205"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-013-1771-0"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182a52553"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2700.120389"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182128512"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20401"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13780","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T05:35:41Z","timestamp":1695533741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":163,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/apt.13780"],"URL":"https:\/\/doi.org\/10.1111\/apt.13780","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}