{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:10:15Z","timestamp":1785845415299,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The proportion of oesophageal adenocarcinoma that is detected concurrently with initial Barrett's oesophagus diagnosis is not well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the proportion of prevalent adenocarcinoma vs. incident adenocarcinoma found during surveillance of Barrett's.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic search of <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and Web of Science (from their inception to 31 May 2015) for cohort studies in adults with Barrett's (nondysplastic Barrett's \u00b1 Barrett's with low\u2010grade dysplasia) with minimum average follow\u2010up of 3 years, and providing numbers of prevalent adenocarcinoma detected (concurrently with Barrett's diagnosis and up to 1 year afterwards) vs. incident adenocarcinoma detected (greater than 1 year after Barrett's diagnosis). Pooled weighted proportions of prevalent and incident adenocarcinoma were calculated, using a random effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On meta\u2010analysis of 13 studies reporting on 603 adenocarcinomas in 9657 Barrett's patients, 85.1% of adenocarcinomas were classified as prevalent [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 78.1\u201390.2%) and 14.9% as incident (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 9.8\u201321.9%), with substantial heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 66%). Among nine studies reporting on 787 high\u2010grade dysplasia and oesophageal adenocarcinomas in 8098 Barrett's patients, the proportion of prevalent high\u2010grade dysplasia\u2010oesophageal adenocarcinoma was similar at 80.5% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 68.1\u201388.8%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 87%). These results remained stable across multiple subgroup analyses including study quality, setting, duration of follow\u2010up and presence of baseline dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our meta\u2010analysis, four of five patients diagnosed with adenocarcinoma or high\u2010grade dysplasia at index endoscopy or within 1 year of Barrett's follow\u2010up were considered to be prevalent cases. Continued efforts are needed to identify patients with Barrett's before the development of adenocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13783","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T10:12:46Z","timestamp":1472206366000},"page":"775-784","source":"Crossref","is-referenced-by-count":30,"title":["Systematic review with meta\u2010analysis: prevalent vs. incident oesophageal adenocarcinoma and high\u2010grade dysplasia in Barrett's oesophagus"],"prefix":"10.1111","volume":"44","author":[{"given":"K.","family":"Visrodia","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Mayo Clinic Rochester MN USA"},{"name":"Division of Gastroenterology University of California San Diego La Jolla CA USA"},{"name":"Division of Biomedical Informatics University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Krishnamoorthi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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