{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:02:14Z","timestamp":1788670934352,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T00:00:00Z","timestamp":1474243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L001489\/1"],"award-info":[{"award-number":["MR\/L001489\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000774","name":"Newcastle University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Age at presentation with primary biliary cholangitis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>) is associated with differential response to ursodeoxycholic acid (<jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content>) therapy. Younger\u2010presenting patients are less likely to respond to treatment and more likely to need transplant or die from the disease. <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> has a complex impact on quality of life (QoL), with systemic symptoms often having significant impact.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explain the impact of age at presentation on perceived QoL and the inter\u2010related symptoms which impact upon it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> cohort, symptoms were assessed using the <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\u201040 and other validated tools. Data were available on 2055 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1990 patients reporting a global <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\u2010QoL score, 66% reported good\/neutral scores and 34% reported poor scores. Each 10\u2010year increase in age at presentation was associated with a 14% decrease in risk of poor perceived QoL (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 0.86, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.75\u20130.98, <jats:italic>P<\/jats:italic> &lt; 0.05). All symptom domains were similarly age\u2010associated (<jats:italic>P<\/jats:italic> &lt; 0.01). Social dysfunction was the symptom factor with the greatest impact on QoL. Median (interquartile range) <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\u201040 social scores for patients with good perceived QoL were 18 (14\u201323) compared with 34 (29\u201339) for those with poor QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of patients with primary biliary cholangitis do not feel their QoL is impaired, although impairment is reported by a sizeable minority. Age at presentation is associated with impact on perceived QoL and the symptoms impairing it, with younger patients being more affected. Social dysfunction makes the greatest contribution to QoL impairment, and it should be targeted in trials aimed at improving life quality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13794","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T04:53:21Z","timestamp":1474260801000},"page":"1039-1050","source":"Crossref","is-referenced-by-count":72,"title":["The inter\u2010relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"44","author":[{"given":"J. K","family":"Dyson","sequence":"first","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle\u2010upon\u2010Tyne UK"},{"name":"NIHR Newcastle Biomedical Research Centre Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Institute of Health and Society Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jopson","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mells","sequence":"additional","affiliation":[{"name":"Department of Hepatology Cambridge University Hospitals NHS Foundation Trust Cambridge UK"},{"name":"Academic Department of Medical Genetics University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bathgate","sequence":"additional","affiliation":[{"name":"Scottish Liver Transplant Unit Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Heneghan","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Neuberger","sequence":"additional","affiliation":[{"name":"Centre for Liver Research NIHR Biomedical Research Unit University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Hirschfield","sequence":"additional","affiliation":[{"name":"Centre for Liver Research NIHR Biomedical Research Unit University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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