{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:50:41Z","timestamp":1792705841640,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Scientific Fund of the Major of the City of Vienna","award":["14033"],"award-info":[{"award-number":["14033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>HIV<\/jats:styled-content>\/HCV<\/jats:styled-content>co\u2010infected patients show accelerated fibrosis progression and higher risk for complications of portal hypertension (PHT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Aim<\/jats:title>To assess the effects of interferon\u2010free therapy on portal pressure, liver histology and plasma biomarkers inHIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected patients withPHT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010two patients with paired hepatic venous pressure gradient (HVPG<\/jats:styled-content>) measurements prior and after successful treatment (SVR<\/jats:styled-content>) with interferon\u2010free regimens were included. Liver stiffness was assessed by transient elastography and biopsies were scored according toMETAVIR<\/jats:styled-content>. Plasma biomarkers were determined byELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall,HVPG<\/jats:styled-content>decreased from 10.7 \u00b1 4.1 mmHg at baseline to 7.4 \u00b1 4.2 mmHg afterHCV<\/jats:styled-content>treatment (\u0394:\u20103.3 \u00b1 2.7 mmHg; p < 0.001). In patients with clinically significantPHT<\/jats:styled-content>(HVPG<\/jats:styled-content>\u226510 mmHg, n = 11),HVPG<\/jats:styled-content>decreased from 14.1 \u00b1 2.9 to 10.4 \u00b1 3.9 mmHg (\u0394:\u20103.7 \u00b1 3.3 mmHg; p = 0.004) and a haemodynamic response (HVPG<\/jats:styled-content>decrease \u226510%) was observed in 73%. In 64% of patients with subclinicalPHT<\/jats:styled-content>(HVPG<\/jats:styled-content>6\u20139 mmHg, n = 11), portal pressure normalised atSVR<\/jats:styled-content>. Mean liver stiffness decreased from 20.8 kPa to 11.5 kPa (\u0394:\u20108.8 \u00b1 7.4 kPa; p < 0.001). Fifty percent (7\/14) of patients with cirrhosis were re\u2010classified asMETAVIR<\/jats:styled-content>\u2264F3 and all patients with decompensated cirrhosis improved their Child\u2013Pugh stage. After successfulHCV<\/jats:styled-content>treatment, 39% still had persistent histological necroinflammatory activity (METAVIR<\/jats:styled-content>A1), which correlated with lessHVPG<\/jats:styled-content>response and more steatosis. While most biomarkers improved withSVR<\/jats:styled-content>,METAVIR<\/jats:styled-content>A1 patients had significantly higher plasma levels of fibrogenic (PDGF<\/jats:styled-content>,TGF<\/jats:styled-content>\u2010\u03b2) and angiogenic (VEGF<\/jats:styled-content>, Angiopoietin1) biomarkers.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Interferon\u2010free therapy reducesPHT<\/jats:styled-content>and halts histological necroinflammatory activity in the majority ofHIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected patients afterSVR<\/jats:styled-content>, which may lead to re\u2010compensation of liver function in cirrhosis. Biomarkers could identify patients with persisting hepatic necroinflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13844","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T01:33:12Z","timestamp":1478568792000},"page":"139-149","source":"Crossref","is-referenced-by-count":94,"title":["Interferon\u2010free regimens improve portal hypertension and histological necroinflammation inHIV<\/scp>\/HCV<\/scp>patients with advanced liver disease"],"prefix":"10.1111","volume":"45","author":[{"given":"P.","family":"Schwabl","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Vienna HIV & Liver Study Group Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mandorfer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology 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