{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:32:16Z","timestamp":1791390736212,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102014R1A2A1A11052136"],"award-info":[{"award-number":["NRF\u20102014R1A2A1A11052136"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The low incidence of Mycobacterium tuberculosis<\/jats:italic> infection and lack of adequate controls have prevented researchers from estimating tuberculosis (TB<\/jats:styled-content>) risk in inflammatory bowel disease (IBD<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Aim<\/jats:title>To evaluate the risk of incident TB<\/jats:styled-content> among IBD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Using the 2011\u20132013 data of the South Korean National Health Insurance (NHI) system, we calculated the incidence rates (IRs), standardised incidence ratio (SIR) and number needed to screen (NNS) for incident TB<\/jats:styled-content> in IBD<\/jats:styled-content> patients compared to the general population in terms of subtype, age, gender and IBD<\/jats:styled-content> medications.<\/jats:p><\/jats:sec>Results<\/jats:title>The IR, SIR and NNS for TB<\/jats:styled-content> in IBD<\/jats:styled-content> patients were 223.9\/100\u00a0000 person\u2010years, 2.64 (2.30\u20133.01) and 446.6 (392.8\u2013517.6), respectively. The TB<\/jats:styled-content> IR in Crohn's disease (CD<\/jats:styled-content>) patients was significantly higher than that in ulcerative colitis (UC<\/jats:styled-content>) patients (340.1\/100\u00a0000 person\u2010years vs. 165.5\/100\u00a0000 person\u2010years, respectively; P\u00a0<\/jats:italic><\u00a00.001). The SIR and NNS for TB<\/jats:styled-content> among CD<\/jats:styled-content> patients were 4.00 (3.59\u20134.45) and 604.2 (506.1\u2013749.6), respectively; those among UC<\/jats:styled-content> patients were 1.95 (1.66\u20132.27) and 294.0 (246.9\u2013363.4). The TB<\/jats:styled-content> IRs in IBD<\/jats:styled-content> patients did not differ significantly by age or gender (P<\/jats:italic>trend<\/jats:sub>\u00a0=\u00a00.505 and P<\/jats:italic>\u00a0=\u00a00.861, respectively). The TB<\/jats:styled-content> IRs among IBD<\/jats:styled-content>\u00a0patients prescribed 5\u2010ASA<\/jats:styled-content>, corticosteroids, immunomodulators and anti\u2010TNF<\/jats:styled-content>\u2010\u03b1 were 143.5, 208.5, 284.6 and 554.1 per 100\u00a0000 person\u2010years, respectively. Among IBD<\/jats:styled-content> patients treated using anti\u2010TNF<\/jats:styled-content>\u2010\u03b1, the TB<\/jats:styled-content> IR was significantly higher than that among all IBD<\/jats:styled-content> patients (P\u00a0<\/jats:italic><\u00a00.001); the SIR and NNS for TB<\/jats:styled-content> were 6.53 (5.99\u20137.09) and 180.5 (144.6\u2013240.1) respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Clinicians should be aware of the increased risk of active tuberculosis in patients with IBD<\/jats:styled-content> who are receiving anti\u2010TNF<\/jats:styled-content>\u2010\u03b1 therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13851","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:25:32Z","timestamp":1478535932000},"page":"253-263","source":"Crossref","is-referenced-by-count":39,"title":["Risk of incident Mycobacterium tuberculosis<\/i> infection in patients with inflammatory bowel disease: a nationwide population\u2010based study in South Korea"],"prefix":"10.1111","volume":"45","author":[{"given":"S. N.","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Public Health Graduate School Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010J.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Public Health Graduate School Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2013.03.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03553.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.12.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.046"},{"key":"e_1_2_7_8_1","volume-title":"Korean Guidelines for Tuberculosis","author":"Joint Committee for the Development of Korean Guidelines for Tuberculosis, Korea Centers for Disease 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