{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:11:12Z","timestamp":1769271072858,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Environmental risk factors associated with ethnicity may contribute to the occurrence of Barrett's metaplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the interaction between ethnicity and<jats:italic>Helicobacter pylori<\/jats:italic>infection in the occurrence of<jats:styled-content style=\"fixed-case\">Barrett's metaplasia<\/jats:styled-content>among patients undergoing oesophago\u2010gastro\u2010duodenoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Miraca Life Sciences Database is an electronic repository of histopathological patient records. A case\u2013control study evaluated the influence of age, gender, ethnicity and histological diagnosis of<jats:italic>H. pylori<\/jats:italic>on the occurrence of Barrett's metaplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total study population comprised 596 479 subjects, of whom 76 475 harboured a diagnosis of Barrett's metaplasia. Male sex, age and<jats:italic>H. pylori<\/jats:italic>infection in declining order exerted the strongest influence on the occurrence of<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>. In comparison with the population comprising Caucasians and African Americans, Barrett's metaplasia was less common among subjects of African (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>= 0.09, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>= 0.01\u20130.43), Middle Eastern (0.26, 0.20\u20130.34), East Asian (0.35, 0.31\u20130.40), Indian (0.39, 0.32\u20130.47), Hispanic (0.62, 0.59\u20130.64) or Jewish descent (0.50, 0.45\u20130.54), but more common among subjects of Northern European descent (1.14, 1.03\u20131.26). With the exception of Jews and Northern Europeans, all other ethnic subgroups were characterised by a higher prevalence of<jats:italic>H. pylori<\/jats:italic>than the comparison group. A low prevalence of<jats:italic>H. pylori<\/jats:italic>was significantly associated with a high prevalence of Barrett's metaplasia (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= 0.82,<jats:italic>P<\/jats:italic>&lt; 0.001), as well as dysplasia or oesophageal adenocarcinoma (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= 0.81,<jats:italic>P<\/jats:italic>&lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our analysis reveals an inverse relationship between the prevalence of Barrett's metaplasia and<jats:italic>H. pylori<\/jats:italic>gastritis among different ethnic groups within the United States.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13854","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T21:26:25Z","timestamp":1478726785000},"page":"283-290","source":"Crossref","is-referenced-by-count":16,"title":["The influence of<i>Helicobacter pylori<\/i>on the ethnic distribution of Barrett's metaplasia"],"prefix":"10.1111","volume":"45","author":[{"given":"A.","family":"Sonnenberg","sequence":"first","affiliation":[{"name":"Miraca Life Sciences Irving TX USA"},{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. O.","family":"Turner","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences Irving TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Spechler","sequence":"additional","affiliation":[{"name":"VA North Texas Health Care System Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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