{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:21:45Z","timestamp":1780572105451,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) is associated with colorectal neoplasia. Yet, <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> ranges from simple steatosis to steatohepatitis with advanced fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the risk of colorectal neoplasia according to the presence and severity of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 26 540 asymptomatic adults who underwent same day first\u2010time colonoscopy and abdominal ultrasonography as a health check\u2010up programme were analysed. <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> was diagnosed by ultrasonography. Advanced colorectal neoplasia was defined as an invasive cancer or adenoma that was at least 10 mm in diameter, had high\u2010grade dysplasia, or had villous histological characteristics or any combination thereof.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> patients had a higher prevalence of any colorectal neoplasia (38.0% vs. 28.9%) and advanced colorectal neoplasia (2.8% vs. 1.9%) compared to those without <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. In a multivariable model adjusted for age, sex, smoking, alcohol, body mass index, first\u2010degree family history of colorectal cancer, aspirin use and metabolic factors, the odd ratios comparing patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> to those without were 1.10 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.03\u20131.17] for any colorectal neoplasia and 1.21 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.99\u20131.47) for advanced colorectal neoplasia. When <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> patients were further stratified according to the non\u2010invasive parameters of liver disease severity, the risk of any colorectal neoplasia or advanced colorectal neoplasia was higher for those with severe liver diseases than those with mild liver diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence and severity of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> were closely associated with any colorectal neoplasia and advanced colorectal neoplasia, suggesting that clinicians should be aware of the increased risk of colorectal neoplasia in patients with NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13866","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T07:33:21Z","timestamp":1479454401000},"page":"345-353","source":"Crossref","is-referenced-by-count":58,"title":["Non\u2010alcoholic fatty liver diseases and risk of colorectal neoplasia"],"prefix":"10.1111","volume":"45","author":[{"given":"J. S.","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. H.","family":"Sinn","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. W.","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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