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Symptoms (heartburn, acid regurgitation, retrosternal pain and acid taste in the mouth) and health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>) were evaluated before and after treatment. The primary endpoint was the proportion of patients with at least a 3\u2010point reduction in the total symptom score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of treatment, the primary endpoint was reached by 52.6% of patients taking Esoxx compared to 32.1% of those given placebo (<jats:italic>P<\/jats:italic> &lt; 0.01). The same was true also for <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>, evaluated by means of the Short Form\u201036 questionnaire, which improved with both treatments, but some items were significantly better after Esoxx plus <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The synergistic effect of Essox with PPI treatment suggests that mucosal protection added to acid suppression could improve symptoms and HRQL in NERD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13914","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T07:38:11Z","timestamp":1485243491000},"page":"631-642","source":"Crossref","is-referenced-by-count":96,"title":["Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non\u2010erosive reflux disease \u2013 efficacy of Esoxx, a hyaluronic acid\u2013chondroitin sulphate based bioadhesive formulation"],"prefix":"10.1111","volume":"45","author":[{"given":"V.","family":"Savarino","sequence":"first","affiliation":[{"name":"Gastroenterology &amp; Digestive Endoscopy Unit Department of Internal Medicine University of Genoa Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pace","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Digestive Endoscopy Bolognini Teaching Hospital Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-857X","authenticated-orcid":false,"given":"C.","family":"Scarpignato","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology &amp; Digestive Pathophysiology Unit Department of Clinical &amp; Experimental Medicine University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Esoxx Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05912.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000219365"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.09.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-0673.2004.01835.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02944.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(12)61554-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40978.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.50209.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0672-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02609.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/646901"},{"key":"e_1_2_7_15_1","unstructured":"PizzoniA.(Inventor). 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