{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:29:17Z","timestamp":1788571757642,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapy for coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) mainly relies on following a gluten\u2010free diet (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>); however, a serum marker for gluten intake has yet to be established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the utility of alkylresorcinol concentrations for detecting gluten intake in studies of human and mouse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Alkylresorcinol concentrations were compared among treated patients with coeliac disease (<jats:italic>n<\/jats:italic> = 34), untreated coeliac disease patients (<jats:italic>n<\/jats:italic> = 36) and controls (<jats:italic>n<\/jats:italic> = 33). Furthermore, seven additional coeliac disease patients whose serum samples were available at diagnosis and after <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> were evaluated. In mice studies, alkylresorcinol concentrations were compared in the serum of five mice fed a regular chow and 10 mice fed lifelong with a gluten\u2010free chow. In addition, the effect of adding gluten on changes of alkylresorcinol concentrations was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total alkylresorcinol concentrations were significantly lower in treated with coeliac disease [median (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>), 3 (2\u20138) nmol\/L], compared to untreated patients [median (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>), 32 (11\u201374) nmol\/L; <jats:italic>P<\/jats:italic> &lt; 0.0001] or healthy controls [median (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>), 54 (23\u2013112) nmol\/L; <jats:italic>P<\/jats:italic> &lt; 0.0001]. Moreover, alkylresorcinol concentrations in coeliac disease patients significantly decreased after introduction of a <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> (median, 34 nmol\/L at diagnosis vs. 5 nmol\/L after <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>,<jats:italic> P<\/jats:italic> = 0.02). In the mice, median (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) total alkylresorcinol concentrations in serum samples of mice fed lifelong with a gluten\u2010free chow was 1.8 (1.6\u20132.3) nmol\/L, which was further significantly increased to 16 (11\u201322) nmol\/L after 8 days of feeding with the gluten\u2010free chow that had gluten added to it. (<jats:italic>P<\/jats:italic> = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum alkylresorcinol concentrations could be a useful marker for dietary gluten in coeliac disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13917","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T05:46:45Z","timestamp":1483508805000},"page":"643-652","source":"Crossref","is-referenced-by-count":15,"title":["Serum alkylresorcinols as biomarkers of dietary gluten exposure in coeliac disease"],"prefix":"10.1111","volume":"45","author":[{"given":"R. S.","family":"Choung","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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