{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:10:30Z","timestamp":1780337430823,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Treatment of chronic hepatitis C genotype 3 (GT<\/jats:styled-content>3) is more challenging compared with other genotypes. Since 2014, several new treatment regimens have been approved but sometimes based on limited data.<\/jats:p><\/jats:sec>Aim<\/jats:title>To validate the use, effectiveness and safety of anti\u2010viral treatment in chronic hepatitis C genotype 3 infection under real\u2010word conditions.<\/jats:p><\/jats:sec>Methods<\/jats:title>The German Hepatitis C\u2010Registry is a large national non\u2010interventional real\u2010world study for patients with chronic hepatitis C. A total of 1322 GT<\/jats:styled-content>3 patients were enrolled (211 untreated and 1111 treated patients).<\/jats:p><\/jats:sec>Results<\/jats:title>Between February 2014 and September 2015, five different treatment strategies have been used (PegIFN<\/jats:styled-content>+RBV<\/jats:styled-content>, PegIFN<\/jats:styled-content>+RBV<\/jats:styled-content>+SOF<\/jats:styled-content>, SOF<\/jats:styled-content>+RBV<\/jats:styled-content>, DCV<\/jats:styled-content>+SOF<\/jats:styled-content>\u00b1RBV<\/jats:styled-content>, LDV<\/jats:styled-content>\/SOF<\/jats:styled-content>\u00b1RBV<\/jats:styled-content>). Treatment uptake and use of treatment concepts changed markedly and rapidly during the study influenced by new approvals, guideline recommendations, and label updates. PegIFN<\/jats:styled-content>\u2010based therapies constantly declined while DCV<\/jats:styled-content>\u2010based therapies increased with one interruption after the approval of LDV<\/jats:styled-content>\/SOF<\/jats:styled-content>, which was frequently used until new guidelines recommended not using this combination for GT<\/jats:styled-content>3. Per\u2010protocol SVR<\/jats:styled-content> ranged from 80.9% in the PegIFN<\/jats:styled-content>+RBV<\/jats:styled-content> group to 96.1% in PegIFN<\/jats:styled-content>+RBV<\/jats:styled-content>+SOF<\/jats:styled-content> treated patients. Treatment\u2010experienced patients with cirrhosis showed a suboptimal SVR<\/jats:styled-content> of 68% for SOF<\/jats:styled-content>+RBV<\/jats:styled-content> but a high SVR<\/jats:styled-content> of 90\u201395% for DCV<\/jats:styled-content>+SOF<\/jats:styled-content>\u00b1RBV<\/jats:styled-content>. The safety analysis showed more adverse events and a stronger decline of haemoglobin for RBV<\/jats:styled-content> containing regimens.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Real\u2010world data can validate the effectiveness and safety for treatment regimens that had previously been approved with limited data, in particular for specific subgroups of patients. The present study demonstrates how rapid new scientific data, new treatment guidelines, new drug approvals and label changes are implemented into routine clinical practice today.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13925","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T10:47:43Z","timestamp":1484218063000},"page":"688-700","source":"Crossref","is-referenced-by-count":37,"title":["Real\u2010world use, effectiveness and safety of anti\u2010viral treatment in chronic hepatitis C genotype 3 infection"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-8001","authenticated-orcid":false,"given":"M.","family":"Cornberg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School, Hannover Germany and German Center for Infection Research (DZIF), Partner\u2010site Hannover\u2010Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Petersen","sequence":"additional","affiliation":[{"name":"IFI\u2010Institute for Interdisciplinary Medicine Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schober","sequence":"additional","affiliation":[{"name":"Hepatologische Praxis G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mauss","sequence":"additional","affiliation":[{"name":"Center for HIV and Hepatogastroenterology Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H. W.","family":"B\u00f6ker","sequence":"additional","affiliation":[{"name":"Hepatologische Praxis Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Link","sequence":"additional","affiliation":[{"name":"MVZ Offenburg Offenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig\u2010Holstein (UKSH) Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Serfert","sequence":"additional","affiliation":[{"name":"Leberstiftungs\u2010GmbH Deutschland Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pfeiffer\u2010Vornkahl","sequence":"additional","affiliation":[{"name":"e.factum GmbH Butzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School, Hannover Germany and German Center for Infection Research (DZIF), Partner\u2010site Hannover\u2010Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sarrazin","sequence":"additional","affiliation":[{"name":"St.\u2010Josefs\u2010Hospital Wiesbaden and University Hospital Frankfurt Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"H\u00fcppe","sequence":"additional","affiliation":[{"name":"Hepatologische Schwerpunktpraxis Herne Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Berg","sequence":"additional","affiliation":[{"name":"University Hospital Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Niederau","sequence":"additional","affiliation":[{"name":"St. Josef\u2010Hospital Katholisches Klinikum Oberhausen Oberhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.144878"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13343"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.02.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12646"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26905"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316145"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27567"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306218"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13264"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27726"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.063"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108751"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.043"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw387"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.05.049"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2016.59099"},{"key":"e_1_2_7_20_1","first-page":"1185","article-title":"[Current recommendations for the treatment of chronic hepatitis C]","volume":"52","author":"Sarrazin C","year":"2014","journal-title":"Z Gastroenterol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512612"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512614"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.09.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28473"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30029-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.029"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(16)01644-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.025"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-963691"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:37:03Z","timestamp":1694432223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/apt.13925"],"URL":"https:\/\/doi.org\/10.1111\/apt.13925","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]}}}