{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:01:02Z","timestamp":1789563662229,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["# 81325002"],"award-info":[{"award-number":["# 81325002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#81620108002"],"award-info":[{"award-number":["#81620108002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#81570511"],"award-info":[{"award-number":["#81570511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#81421001"],"award-info":[{"award-number":["#81421001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#81400608"],"award-info":[{"award-number":["#81400608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Adequate risk stratification is critical for the management of the patients with primary biliary cholangitis (PBC<\/jats:styled-content>). The UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> and GLOBE<\/jats:styled-content> scoring systems for prognosis of PBC<\/jats:styled-content> have been proposed recently, but have not been validated in Asian population.<\/jats:p><\/jats:sec>Aim<\/jats:title>To validate the UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> and GLOBE<\/jats:styled-content> scoring systems in Chinese patients for prognosis of PBC<\/jats:styled-content>. To clarify the role of anti\u2010gp210 as a biomarker, and to investigate whether anti\u2010gp210 could affect the prognostic values of UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> and GLOBE<\/jats:styled-content> scoring systems.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively analysed 276 patients with PBC<\/jats:styled-content> evaluated between September 2004 and May 2016, including 133 anti\u2010gp210+ and 143 anti\u2010gp210\u2212 patients.<\/jats:p><\/jats:sec>Results<\/jats:title>The 5\u2010year adverse outcome\u2010free survivals of anti\u2010gp210+ vs. anti\u2010gp210\u2212 patients were 70% and 85%, respectively (P<\/jats:italic> = 0.005). Cirrhosis (P<\/jats:italic> = 0.001), albumin level \u226440 g\/L (P<\/jats:italic> = 0.011) and platelet count \u2264153 \u00d7 109<\/jats:sup> (P<\/jats:italic> < 0.001) had a superimposition effect on anti\u2010gp210 antibody as a risk factor. Furthermore, long\u2010term prognoses were evaluated using the UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> and GLOBE<\/jats:styled-content> scores. For UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> scoring system, the area under receiver operating characteristic curve (AUROC<\/jats:styled-content>) was 0.924 for all patients with PBC<\/jats:styled-content> (n<\/jats:italic> = 223), 0.940 for anti\u2010gp210+ patients (n<\/jats:italic> = 110) and 0.888 for anti\u2010gp210\u2212 patients (n<\/jats:italic> = 113). For GLOBE<\/jats:styled-content> scoring system, the area under receiver operating characteristic curve was 0.901 for all patients with PBC<\/jats:styled-content> (n<\/jats:italic> = 223), 0.924 for anti\u2010gp210+ patients (n<\/jats:italic> = 110) and 0.848 for anti\u2010gp210\u2212 patients (n<\/jats:italic> = 113). UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> score >0.0578 (P<\/jats:italic> < 0.001, HR<\/jats:styled-content>: 32.736, 95% CI<\/jats:styled-content>: 11.368\u201394.267) and GLOBE<\/jats:styled-content> score <0.850 (P<\/jats:italic> < 0.001, HR<\/jats:styled-content>: 18.763, 95% CI<\/jats:styled-content>: 7.968\u201344.180) were associated with poorer outcomes in the whole cohort.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> and GLOBE<\/jats:styled-content> scoring systems were good 5\u2010year prognostic predictors in Chinese patients with PBC<\/jats:styled-content>, especially in anti\u2010gp210+ patients. As a biomarker, anti\u2010gp210 antibody was associated with a more severe cholestatic manifestation and a worse long\u2010term prognosis. The anti\u2010gp210 antibody could be added to further optimise the UK<\/jats:styled-content>\u2010PBC<\/jats:styled-content> and GLOBE<\/jats:styled-content> scoring systems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13927","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:10:52Z","timestamp":1484320252000},"page":"733-743","source":"Crossref","is-referenced-by-count":83,"title":["The risk predictive values of UK<\/scp>\u2010PBC<\/scp> and GLOBE<\/scp> scoring system in Chinese patients with primary biliary cholangitis: the additional effect of anti\u2010gp210"],"prefix":"10.1111","volume":"45","author":[{"given":"F.","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Miao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nantong Institute of Liver Disease Nantong Third People's Hospital Nantong University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sheng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Qiu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Gershwin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Clinical Immunology University of California at Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-2708","authenticated-orcid":false,"given":"X.","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28140"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.4049\/jimmunol.139.11.3828","article-title":"Molecular cloning of the liver\u2010specific rat F antigen","volume":"139","author":"Gershwin ME","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043898"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.08.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8516-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.11.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8484-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.10.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.07.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8502-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230512"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07257.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21472"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12423"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22428"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.031"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.029"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.216"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12522"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.061"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.01.029"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26322"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22906"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.07.002"},{"key":"e_1_2_7_30_1","article-title":"A comprehensive overview on myositis\u2010specific antibodies: new and old biomarkers in idiopathic inflammatory myopathy","author":"Satoh M","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.11.003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8459-2"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:37:06Z","timestamp":1694432226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/apt.13927"],"URL":"https:\/\/doi.org\/10.1111\/apt.13927","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}