{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:47:12Z","timestamp":1788670032946,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK043351"],"award-info":[{"award-number":["P30DK043351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 DK097142"],"award-info":[{"award-number":["K23 DK097142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory bowel diseases lead to progressive bowel damage and need for surgery. While the increase in prevalence of other immune\u2010mediated diseases in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> is well recognised, the impact of this on the natural history of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the impact of concomitant immune\u2010mediated diseases on phenotypes and outcomes in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> enrolled in a prospective registry were queried about the presence of other immune\u2010mediated diseases, defined as those where immune dysregulation plays a role in pathogenesis. Demographics and disease\u2010related information were obtained. Subjects also completed measures of quality of life. Multivariable regression models compared disease phenotype and outcomes of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients with and without other immune\u2010mediated diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 2145 <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients among whom 458 (21%) had another immune\u2010mediated disease. There was no difference in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> phenotype between the two groups. <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients were more likely to have pancolitis in the presence of another immune\u2010mediated disease (62%) compared to those without (52%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients with another immune\u2010mediated disease had higher rates of needing anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> biologics [Odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1.31, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05\u20131.63] and surgery (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.26, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.99\u20131.61). The presence of another immune\u2010mediated disease was also associated with lower disease\u2010specific and general physical quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of another immune\u2010mediated disease in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients was associated with higher likelihood of pancolonic involvement in <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>, and a modest increase in need for <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\u2010related surgery and anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> biological therapy. Such patients also experienced worse quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13940","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T15:41:00Z","timestamp":1484926860000},"page":"814-823","source":"Crossref","is-referenced-by-count":40,"title":["The impact of co\u2010existing immune\u2010mediated diseases on phenotype and outcomes in inflammatory bowel diseases"],"prefix":"10.1111","volume":"45","author":[{"given":"G.","family":"Conway","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Velonias","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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