{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:22:46Z","timestamp":1788384166922,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42ES010337"],"award-info":[{"award-number":["P42ES010337"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004426","name":"Atlantic Philanthropies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000909","name":"John A. Hartford Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009560","name":"American Gastroenterological Association","doi-asserted-by":"publisher","award":["K23\u2010DK090303"],"award-info":[{"award-number":["K23\u2010DK090303"]}],"id":[{"id":"10.13039\/100009560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Magnetic resonance imaging\u2010derived measures of liver fat and volume are emerging as accurate, non\u2010invasive imaging biomarkers in non\u2010alcoholic steatohepatitis (NASH<\/jats:styled-content>). Little is known about these measures in relation to histology longitudinally.<\/jats:p><\/jats:sec>Aim<\/jats:title>To examine any relationship between MRI<\/jats:styled-content>\u2010derived proton\u2010density fat\u2010fraction (PDFF<\/jats:styled-content>), total liver volume (TLV<\/jats:styled-content>), total liver fat index (TLFI<\/jats:styled-content>), vs. histology in a NASH<\/jats:styled-content> trial.<\/jats:p><\/jats:sec>Methods<\/jats:title>This is a secondary analysis of a 24\u2010week randomised, double\u2010blind, placebo\u2010controlled trial of 50 patients with biopsy\u2010proven NASH<\/jats:styled-content> randomised to oral ezetimibe 10 mg daily (n<\/jats:italic> = 25) vs. placebo (n<\/jats:italic> = 25). Baseline and post\u2010treatment anthropometrics, biochemical profiling, MRI<\/jats:styled-content> and biopsies were obtained.<\/jats:p><\/jats:sec>Results<\/jats:title>Baseline mean PDFF<\/jats:styled-content> correlated strongly with TLFI<\/jats:styled-content> (Spearman's \u03c1<\/jats:italic> = 0.94, n<\/jats:italic> = 45, P<\/jats:italic> < 0.0001) and had good correlation with TLV<\/jats:styled-content> (\u03c1<\/jats:italic> = 0.57, n<\/jats:italic> = 45, P<\/jats:italic> < 0.0001). Mean TLV<\/jats:styled-content> correlated strongly with TLFI<\/jats:styled-content> (\u03c1<\/jats:italic> = 0.78, n<\/jats:italic> = 45, P<\/jats:italic> < 0.0001). After 24 weeks, PDFF<\/jats:styled-content> remained strongly correlated with TLFI<\/jats:styled-content> (\u03c1<\/jats:italic> = 0.94, n<\/jats:italic> = 45, P<\/jats:italic> < 0.0001), maintaining good correlation with TLV<\/jats:styled-content> (\u03c1<\/jats:italic> = 0.51, n<\/jats:italic> = 45, P<\/jats:italic> = 0.0004). TLV<\/jats:styled-content> remained strongly correlated with TLFI<\/jats:styled-content> (\u03c1<\/jats:italic> = 0.74, n<\/jats:italic> = 45, P<\/jats:italic> < 0.0001). Patients with Grade 1 vs. 3 steatosis had lower PDFF<\/jats:styled-content>, TLV<\/jats:styled-content>, and TLFI<\/jats:styled-content> (P<\/jats:italic> < 0.0001, P<\/jats:italic> = 0.0003, P<\/jats:italic> < 0.0001 respectively). Regression analysis of changes in MRI<\/jats:styled-content>\u2010PDFF<\/jats:styled-content> vs. TLV<\/jats:styled-content> indicates that 10% reduction in MRI<\/jats:styled-content>\u2010PDFF<\/jats:styled-content> predicts 257 mL<\/jats:styled-content> reduction in TLV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The MRI<\/jats:styled-content>\u2010PDFF<\/jats:styled-content> and TLV<\/jats:styled-content> strongly correlated with TLFI<\/jats:styled-content>. Decreases in steatosis were associated with an improvement in hepatomegaly. Lower values of these measures reflect lower histologic steatosis grades. MRI<\/jats:styled-content>\u2010derived measures of liver fat and volume may be used as dynamic and more responsive imaging biomarkers in a NASH<\/jats:styled-content> trial, than histology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13951","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T07:36:56Z","timestamp":1485243416000},"page":"844-854","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of treatment response in non\u2010alcoholic steatohepatitis using advanced magnetic resonance imaging"],"prefix":"10.1111","volume":"45","author":[{"given":"S. C.","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA"},{"name":"NAFLD Research Center University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Heba","sequence":"additional","affiliation":[{"name":"Liver Imaging Group Department of Radiology University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"NAFLD Research Center University of California at San Diego La Jolla CA USA"},{"name":"Division of Epidemiology Department of Family Medicine and Public Health University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Valasek","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Lunde","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Liver Imaging Group Department of Radiology University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Sirlin","sequence":"additional","affiliation":[{"name":"Liver Imaging Group Department of Radiology University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-9991","authenticated-orcid":false,"given":"R.","family":"Loomba","sequence":"additional","affiliation":[{"name":"NAFLD Research Center University of California at San Diego La Jolla CA USA"},{"name":"Division of Epidemiology Department of Family Medicine and Public Health University of California at San Diego La Jolla CA USA"},{"name":"Division of Gastroenterology University of California at San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25762"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2010.00471.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23594"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912063"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.10.1180"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26465"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.052"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.038"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22514"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22580"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25731"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26455"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.65"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.026"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0175-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.08.039"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.243"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347407"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X15621232"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27647"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.11.027"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12237"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/498296"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2015.03.010"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010016\u20100912\u20107"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.011"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27362"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61933-4"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13620"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11901-015-0263-9"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.05.023"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12186"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.08.001"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i13.1560"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05121.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.01.027"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27678"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:13:56Z","timestamp":1695471236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/apt.13951"],"URL":"https:\/\/doi.org\/10.1111\/apt.13951","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]}}}