{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:36:10Z","timestamp":1790033770193,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001720","name":"Nutricia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001720","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophilic oesophagitis (EoE) is a chronic disease, driven by food allergens. Elemental diets are effective for the management of children with EoE, but studies on the effect of elemental diets in adults are scarce and poor palatability challenges dietary adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the effects of an elemental diet (Neocate, Nutricia, Utrecht, the Netherlands) on the inflammation, symptoms and endoscopic signs in adult EoE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, 21 patients with active EoE, confirmed by biopsies showing \u226515 eosinophils per microscopic high power field (<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>) and symptoms of oesophageal dysfunction were included. Patients underwent endoscopy before and 4 weeks after diet. Histological disease activity (peak eosinophil count\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>), and endoscopic signs were scored by physicians. Symptoms and adherence to the diet were evaluated by questionnaires. Serum total IgE levels and total eosinophil counts were determined and the expression of inflammatory cytokines was analysed by <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 17 (81%) of the patients completed the diet, of whom 12 (71%) showed complete histological response (\u226415 eosinophils\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>) and 4 (24%) showed partial histological response (\u226550% reduction of baseline eosinophil count). Peak eosinophil counts decreased significantly after the diet from 40 to 9 per <jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content> (<jats:italic>P<\/jats:italic> \u2264 0.001). A marked improvement in endoscopic signs was observed. Symptoms decreased significantly in all subjects, and 15 patients (88%) became completely asymptomatic (<jats:italic>P<\/jats:italic> \u2264 0.001). In 14 patients (82%), blood eosinophil count and serum IgE decreased (<jats:italic>P<\/jats:italic> \u2264 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elemental diet reduces eosinophilic inflammation and induces clinical remission in adult patients with eosinophilic oesophagitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13953","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T11:03:02Z","timestamp":1485169382000},"page":"777-787","source":"Crossref","is-referenced-by-count":94,"title":["Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-425X","authenticated-orcid":false,"given":"M. J.","family":"Warners","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Academic Medical Centre Amsterdam the Netherlands"},{"name":"Tytgat Institute for Liver and GI Research Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Vlieg\u2010Boerstra","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Onze Lieve Vrouwe Gasthuis Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Verheij","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. D.","family":"van Rhijn","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Centre Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T. J.","family":"Van Ampting","sequence":"additional","affiliation":[{"name":"Nutricia Research Nutricia Advanced Medical Nutrition Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. F.","family":"Harthoorn","sequence":"additional","affiliation":[{"name":"Nutricia Research Nutricia Advanced Medical Nutrition Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and GI Research Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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