{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:39:51Z","timestamp":1785832791335,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with Barrett's oesophagus may be at increased risk of mortality overall, and cardiovascular disease has been suggested as the main underlying cause of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine cause\u2010specific mortality and risk of cardiovascular events among patients with Barrett's oesophagus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilising existing Danish data sources (1997\u20132011), we identified all patients with histologically verified Barrett's oesophagus (<jats:italic>n<\/jats:italic> = 13 435) and 123 526 members of the general population matched by age, sex and individual comorbidities. We calculated cause\u2010specific mortality rates and incidence rates of cardiovascular diseases. We then compared rates between patients with Barrett's oesophagus and the general population comparison cohort, using stratified Cox proportional hazard regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with Barrett's oesophagus had a 71% increased risk of overall mortality. The cause\u2010specific mortality rate per 1000 person\u2010years for patients with Barrett's oesophagus was 8.5 for cardiovascular diseases, 14.7 for non\u2010oesophageal cancers, and 5.4 for oesophageal cancer. Compared to the general population cohort, corresponding hazard ratios were 1.26 (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.15\u20131.38), 1.77 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.65\u20131.90), and 19.4 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 16.1\u201323.4), respectively. The incidence rates of cardiovascular diseases per 1000 person\u2010years for Barrett's oesophagus patients and for persons from the general population cohort, respectively, varied from 0.4 and 0.2 for subarachnoid bleeding (hazard ratio 1.10, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.87\u20131.39) to 8.1 and 5.9 for congestive heart failure (hazard ratio 1.33, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.21\u20131.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic measures targeted at cardiovascular diseases and non\u2010oesophageal cancers potentially could be more important than measures against oesophageal cancer, for improving prognosis among patients with Barrett's oesophagus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13962","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T07:33:44Z","timestamp":1485848024000},"page":"973-982","source":"Crossref","is-referenced-by-count":19,"title":["Mortality and cardiovascular diseases risk in patients with Barrett's oesophagus: a population\u2010based nationwide cohort study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-9185","authenticated-orcid":false,"given":"R.","family":"Erichsen","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Horvath\u2010Puho","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Lund","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health University of North Carolina Chapel Hill USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. S.","family":"Dellon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina School of Medicine Chapel Hill USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health University of North Carolina Chapel Hill USA"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina School of Medicine Chapel Hill USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Davey Smith","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit (IEU) School of Social and Community Medicine University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. T.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60487-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.050"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.10.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.5"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Cancer incidence and mortaltiy sisks in a large US Barrett's esophagus cohort","author":"Cook MB","year":"2017","journal-title":"Gut"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103042"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr203"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300730"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03582.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0432"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.048"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00340.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.04.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1081"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399958"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.09.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5462.2398"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S9908"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1309842"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00745-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.004"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(02)00090-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.031"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.322"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T03:38:12Z","timestamp":1694403492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/apt.13962"],"URL":"https:\/\/doi.org\/10.1111\/apt.13962","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}