{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:41:40Z","timestamp":1778024500793,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The pathophysiology of functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) remains unknown. Duodenal eosinophil infiltration has been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the association between dyspeptic symptoms and duodenal eosinophilia in children undergoing upper gastrointestinal endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, children with normal upper endoscopy and routine histology at a single tertiary paediatric centre between 2010 and 2014 were included. <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> was defined as epigastric pain or discomfort &gt;2 months without response to acid suppression. Controls presented with nonerosive reflux disease, dysphagia or rumination syndrome. Intramucosal eosinophil counts were compared between the groups using uni\u2010 and multivariate regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six cases and 36 nonmatched controls were identified. Atopic history (39% vs. 25%) and psychological comorbidity (53% vs. 39%; both <jats:italic>P<\/jats:italic> = 0.2) were frequent in cases and controls. Self\u2010reported nausea (64% vs. 17%; <jats:italic>P<\/jats:italic> &lt; 0.0001), lethargy (19% vs. 0%; <jats:italic>P<\/jats:italic> = 0.005) and family functional gastrointestinal disorder(<jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>) (28% vs. 3%; <jats:italic>P<\/jats:italic> = 0.003) were more common in cases than controls. Duodenal eosinophil counts [median (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>): 151 (118\u2013207) vs. 76 (60\u2013106) per mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic> &lt; 0.001] were significantly higher in cases than controls with &gt;112 eosinophils per mm<jats:sup>2<\/jats:sup> predictive for <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 33.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 7.1\u2013159.0; <jats:italic>P<\/jats:italic> &lt; 0.001). Duodenal eosinophilia was associated with weight loss (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 7.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.1\u201345.5; <jats:italic>P<\/jats:italic> = 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Functional dyspepsia in children is strongly associated with duodenal eosinophilia, in the absence of endoscopic or routine histological findings. Frequent atopic and psychological comorbidity illustrate likely multifactorial mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14045","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T15:08:16Z","timestamp":1490195296000},"page":"1358-1364","source":"Crossref","is-referenced-by-count":68,"title":["Functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort"],"prefix":"10.1111","volume":"45","author":[{"given":"L.","family":"Wauters","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nightingale","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology John Hunter Children's Hospital Newcastle NSW Australia"},{"name":"Priority Research Centre GrowUpWell University of Newcastle Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Talley","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Anatomical Pathology John Hunter Hospital Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-0056","authenticated-orcid":false,"given":"M. M.","family":"Walker","sequence":"additional","affiliation":[{"name":"Anatomical Pathology John Hunter Hospital Newcastle NSW Australia"},{"name":"Anatomical Pathology University of Newcastle Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii60"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.73"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12542"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2004.04.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.3.251"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.043"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200209000-00017"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992280604500205"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04282.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12419"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01220.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0197-5"},{"key":"e_1_2_7_18_1","first-page":"1026","article-title":"Upper gastrointestinal symptoms and asthma: a manifestation of allergy?","volume":"57","author":"Powell N","year":"2008","journal-title":"Gut"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200403000-00021"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-32"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.007"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.039"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1363c"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01935.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.10"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501505"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303857"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.158"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000740"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-275"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318267c353"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.01.008"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000161972.60610.0E"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.7"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i24.7545"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13006"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.00104"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:36:27Z","timestamp":1695548187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/apt.14045"],"URL":"https:\/\/doi.org\/10.1111\/apt.14045","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,21]]}}}