{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:15:27Z","timestamp":1773551727299,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A repeat biopsy is recommended, but often omitted in coeliac disease patients on a gluten\u2010free diet. The effect of performing or not performing repeat biopsies is currently unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify factors associated with and the significance of lacking biopsy for long\u2010term outcome. Predictors and the importance of incomplete histological recovery after 1\u00a0year was investigated in re\u2010biopsied patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 760 patients participated in a nationwide follow\u2010up study. Medical data were gathered via interviews and patient records, and blood samples were drawn for serology. Current symptoms and well\u2010being were assessed by validated <jats:styled-content style=\"fixed-case\">PGWB<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SF<\/jats:styled-content>\u201036 and <jats:styled-content style=\"fixed-case\">GSRS<\/jats:styled-content> questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Malabsorption was more common among those with a repeat biopsy (46%) than those without repeat biopsy (33%), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, as were severe symptoms at diagnosis (24% vs. 16%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) and concomitant gastrointestinal (40% vs. 32%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049) or musculoskeletal (35% vs. 27%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023) diseases such as arthritis, osteoporosis and back pain. Repeat biopsy was more rare in subjects diagnosed in private care (11% vs. 23%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) or by screening (10% vs. 16%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010). The groups were comparable as to current symptoms and dietary adherence, but those without re\u2010biopsy were less confident of their diet (89% vs. 94%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and more often seropositive on diet (14% vs. 9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). They reported better <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 physical functioning (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) and less pain and indigestion (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046 respectively) and total <jats:styled-content style=\"fixed-case\">GSRS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.052) score. Incomplete mucosal recovery was predicted by more advanced histological (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and serological (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) disease at diagnosis, whereas the groups did not differ in long\u2010term adherence, symptoms, seropositivity, questionnaire scores, frequency of fractures or malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe disease at diagnosis predicted the record of a repeat biopsy and incomplete mucosal recovery. Neither lacking biopsy nor incomplete recovery in a relative short time span of 1\u00a0year was associated with poorer long\u2010term outcome, although survival bias cannot be excluded.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14048","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T20:36:05Z","timestamp":1490214965000},"page":"1459-1468","source":"Crossref","is-referenced-by-count":35,"title":["Performing routine follow\u2010up biopsy 1\u00a0year after diagnosis does not affect long\u2010term outcomes in coeliac disease"],"prefix":"10.1111","volume":"45","author":[{"given":"H.","family":"Pekki","sequence":"first","affiliation":[{"name":"The Faculty of Medicine and Life Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-2164","authenticated-orcid":false,"given":"K.","family":"Kurppa","sequence":"additional","affiliation":[{"name":"Tampere Center for 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