{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:46:06Z","timestamp":1790891166393,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["(CU\u201058\u2010001\u2010HR)"],"award-info":[{"award-number":["(CU\u201058\u2010001\u2010HR)"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Gastric intestinal metaplasia (\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      ) is the premalignant stage of gastric cancer; however, consensus on its management has not been established.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To determine the risk factors for gastric cancer in a population of patients with\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      to guide the appropriate clinical recommendations in a low prevalence area for gastric cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective cohort study. Ninety\u2010one patients with\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      diagnosed between 2004 and 2014 were recruited for surveillance\n                      <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>\n                      every 6\u201012\u00a0months until a diagnosis of gastric cancer or completion of the planned 5\u2010year follow\u2010up duration. Possible risk factors for gastric cancer were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At initial presentation, 81 of the 91 patients (89%) had complete\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      , whereas the remaining 11% had a study entry diagnosis of incomplete\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      . No cancer developed amongst patients with complete\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      . In contrast, five of the 10 patients exhibiting incomplete\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      (50%) progressed to high\u2010grade dysplasia (n=2) or cancer (n=3). Male gender (\n                      <jats:italic>P<\/jats:italic>\n                      =.027), and incomplete\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      =.001) were associated with high\u2010risk histology (dysplasia or cancer) by study end. A trend suggested a possible association with smoking (\n                      <jats:italic>P<\/jats:italic>\n                      =.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Male patients and those with incomplete\n                      <jats:styled-content style=\"fixed-case\">GIM<\/jats:styled-content>\n                      are at greatest risk of developing dysplasia or early gastric cancer. Further studies in determining optimal surveillance intervals and impact on cancer incidence and mortality are still required.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.14082","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T17:26:50Z","timestamp":1493314010000},"page":"40-45","source":"Crossref","is-referenced-by-count":58,"title":["The risk of gastric cancer in patients with gastric intestinal metaplasia in 5\u2010year follow\u2010up"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-5245","authenticated-orcid":false,"given":"R.","family":"Pittayanon","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Bangkok Thailand"},{"name":"Division of Gastroenterology McGill University and the McGill University Health Centre Montreal QC 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