{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:11:17Z","timestamp":1793254277508,"version":"4.5.0"},"reference-count":149,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hepatitis E virus (\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      ) is a leading cause of acute icteric hepatitis and acute liver failure in the developing world. During the last decade, there has been increasing recognition of autochthonous (locally acquired)\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection in developed countries. Chronic\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection is now recognised, and in transplant recipients this may lead to cirrhosis and organ failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To detail current understanding of the molecular biology of\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      , diagnostic and therapeutic strategies and propose future directions for basic science and clinical research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed was searched for English language articles using the key words \u201chepatitis E\u201d, \u201cviral hepatitis\u201d, \u201cautochthonous infection\u201d, \u201cantiviral therapy\u201d, \u201cliver transplantation\u201d, \u201cacute\u201d, \u201cchronic\u201d, \u201c\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      \u201d, \u201cgenotype\u201d, \u201ctransmission\u201d \u201cfood\u2010borne\u201d, \u201ctransfusion\u201d. Additional relevant publications were identified from article reference lists.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There has been increasing recognition of autochthonous\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection in Western countries, mainly associated with genotype 3. Chronic\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection has been recognised since 2008, and in transplant recipients this may lead to cirrhosis and organ failure. Modes of transmission include food\u2010borne transmission, transfusion of blood products and solid organ transplantation. Ribavirin therapy is used to treat patients with chronic\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection, but new therapies are required as there have been reports of treatment failure with ribavirin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Autochthonous\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection is a clinical issue with increasing burden. Future work should focus on increasing awareness of\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection in the developed world, emphasising the need for clinicians to have a low threshold for\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      testing, particularly in immunosuppressed patients. Patients at potential risk of chronic\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infection must also be educated and given advice regarding prevention of infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.14109","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T17:41:58Z","timestamp":1493314918000},"page":"126-141","source":"Crossref","is-referenced-by-count":84,"title":["Review article: hepatitis E\u2014a concise review of virology, epidemiology, clinical presentation and therapy"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-7284","authenticated-orcid":false,"given":"M. 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