{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:58:28Z","timestamp":1768525108945,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"St. Vincent's Clinic Foundation Research","award":["2013"],"award-info":[{"award-number":["2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Serum macrophage inhibitory cytokine\u20101 (MIC<\/jats:styled-content>\u20101\/GDF<\/jats:styled-content>15) concentration has been associated with colonic adenomas and carcinoma.<\/jats:p><\/jats:sec>Aims<\/jats:title>To determine whether circulating MIC<\/jats:styled-content>\u20101\/GDF<\/jats:styled-content>15 serum concentrations are higher in the presence of adenomas and whether the level decreases after excision.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients were recruited prospectively from a single centre and stratified into five groups: no polyps (NP<\/jats:styled-content>); hyperplastic polyps (HP<\/jats:styled-content>); sessile serrated ademona (SSA<\/jats:styled-content>); adenomas (AP<\/jats:styled-content>); and colorectal carcinoma (CRC<\/jats:styled-content>). Blood samples were collected immediately before and 4 weeks after colonoscopy. MIC<\/jats:styled-content>\u20101\/GDF<\/jats:styled-content>15 serum levels were quantified using ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Participants (n=301) were stratified as: NP<\/jats:styled-content>; n=116 (52%), HP<\/jats:styled-content>; n=37 (12%), SSA<\/jats:styled-content>; n=19 (7%), AP<\/jats:styled-content>; n=68 (23%); and CRC<\/jats:styled-content>; n=3 (1%). Patients were excluded from the study due to nondiagnostic pathology (n=9, 3%) and exclusion criteria (n=20, 6%). In the 272 remaining subjects (M=149; F=123), age (P<\/jats:italic>=.005), history of colonic polyps (P<\/jats:italic>=.003) and family history of colonic polyps (P<\/jats:italic>=.002) were associated with presence of adenomas. Baseline median MIC<\/jats:styled-content>\u20101\/GDF<\/jats:styled-content>15 serum levels increased significantly from NP<\/jats:styled-content> 609 (460\u2010797) pg\/mL<\/jats:styled-content>, HP<\/jats:styled-content> 582 (466\u2010852) pg\/mL<\/jats:styled-content>, SSA<\/jats:styled-content> 561 (446\u2010837) pg\/mL<\/jats:styled-content> to AP<\/jats:styled-content> 723 (602\u20101122) pg\/mL<\/jats:styled-content> and CRC<\/jats:styled-content> 1107 (897\u20101107) pg\/mL<\/jats:styled-content>; (P<\/jats:italic><.001). In the pre\u2010 and postpolypectomy paired adenoma samples median MIC<\/jats:styled-content>\u20101\/GDF<\/jats:styled-content>15 reduced significantly from 722 (603\u20101164) pg\/mL<\/jats:styled-content> to 685 (561\u2010944) pg\/mL<\/jats:styled-content> (P<\/jats:italic>=.002). A ROC<\/jats:styled-content> analysis for serum MIC<\/jats:styled-content>\u20101\/GDF<\/jats:styled-content>15 to identify adenomatous polyps indicated an area under the curve of 0.71.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our data suggest that serum MIC<\/jats:styled-content>\u20101\/GDF<\/jats:styled-content>15 has the diagnostic characteristics to increase the detection of colonic neoplasia and improve screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14156","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T10:36:43Z","timestamp":1496313403000},"page":"347-354","source":"Crossref","is-referenced-by-count":16,"title":["Macrophage inhibitory cytokine\u20101\/growth differentiation factor\u201015 as a predictor of colonic neoplasia"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-6811","authenticated-orcid":false,"given":"M.","family":"Danta","sequence":"first","affiliation":[{"name":"St Vincent's Clinical School Faculty of Medicine UNSW Sydney NSW Australia"},{"name":"Department of Gastroenterology St Vincent's Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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