{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:45:00Z","timestamp":1789584300241,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","award":["13409"],"award-info":[{"award-number":["13409"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","award":["21691"],"award-info":[{"award-number":["21691"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","award":["21692"],"award-info":[{"award-number":["21692"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005760","name":"G\u00f6teborgs Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Current subgrouping of Irritable Bowel Syndrome (\n IBS<\/jats:styled-content>\n ) is exclusively based on stool consistency without considering other relevant gastrointestinal (\n GI<\/jats:styled-content>\n ), extraintestinal somatic or psychological features.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To identify subgroups based on a comprehensive set of\n IBS<\/jats:styled-content>\n \u2010related parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Mixture model analysis was used, with the following input variables: 13 single\u2010item scores from the\n IBS<\/jats:styled-content>\n \u2010specific Gastrointestinal Symptom Rating Scale, average stool consistency and frequency from a 7\u2010day Bristol Stool Form diary, 12 single\u2010item extraintestinal symptom scores from the Patient Health Questionnaire\u201012, and anxiety and depression subscale scores from the Hospital Anxiety and Depression scale. The resulting latent subgroups were compared regarding symptom profiles using analysis of variance followed by pair\u2010wise comparisons.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and seventy\u2010two\n IBS<\/jats:styled-content>\n patients (Rome\n III<\/jats:styled-content>\n ; 69% female; mean age 33.7 [range 18\u201060] years) were included. The optimal subgrouping showed six latent groups, characterised by: (I) constipation with low comorbidities, (\n II<\/jats:styled-content>\n ) constipation with high comorbidities, (\n III<\/jats:styled-content>\n ) diarrhoea with low comorbidities, (\n IV<\/jats:styled-content>\n ) diarrhoea and pain with high comorbidities, (V) mixed\n GI<\/jats:styled-content>\n symptoms with high comorbidities, (\n VI<\/jats:styled-content>\n ) a mix of symptoms with overall mild severity. The subgroups showed differences in the distribution of Rome\n III<\/jats:styled-content>\n \u2010subtypes,\n IBS<\/jats:styled-content>\n severity, presence of anxiety and depression, and gender, but not regarding age,\n IBS<\/jats:styled-content>\n duration or reported post\u2010infectious onset of\n IBS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This model\u2010based subgrouping of\n IBS<\/jats:styled-content>\n partly supports the distinction of subgroups based on bowel habits, but additionally distinguishes subgroups with or without co\u2010morbid extraintestinal somatic and psychological symptoms. The resulting groups show specific profiles of symptom combinations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.14207","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T05:06:41Z","timestamp":1499058401000},"page":"529-539","source":"Crossref","is-referenced-by-count":57,"title":["Mixture model analysis identifies irritable bowel syndrome subgroups characterised by specific profiles of gastrointestinal, extraintestinal somatic and psychological symptoms"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-7051","authenticated-orcid":false,"given":"A.","family":"Polster","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Van Oudenhove","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Psychology Department Faculty of Human Sciences Macquarie University North Ryde NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"\u00d6hman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"T\u00f6rnblom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Simr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Center for Functional Gastrointestinal and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.14"},{"key":"e_1_2_7_6_1","first-page":"24","article-title":"Quality of life in managed care patients with irritable bowel syndrome","volume":"17","author":"Wilson A","year":"2004","journal-title":"Manag Care Interface"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12982"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07296.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30116-9"},{"key":"e_1_2_7_11_1","first-page":"II25","article-title":"Psychosocial aspects of the functional gastrointestinal disorders","volume":"45","author":"Drossman DA","year":"1999","journal-title":"Gut"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32392"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.027"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.1.37"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00083-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12886"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310004209"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200203000-00008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04402.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_7_24_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"e_1_2_7_25_1","unstructured":"JosseJ HussonF.missMDA: a package to handle missing values in and with multivariate exploratory data analysis methods. 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