{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:00:18Z","timestamp":1790352018933,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The combination of pepsinogen, gastrin\u201017 and anti\u2010\n                      <jats:italic>H. pylori<\/jats:italic>\n                      antibodies serological assays (panel test) is a non\u2010invasive tool for the diagnosis of atrophic gastritis. However, the diagnostic reliability of this test is still uncertain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the diagnostic performance of the serum panel test for the diagnosis of atrophic gastritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medline via PubMed, Embase, Scopus, Cochrane Library databases and abstracts of international conferences proceedings were searched from January 1995 to December 2016 using the primary keywords \u201cpepsinogens,\u201d \u201cgastrin,\u201d \u201catrophic gastritis,\u201d \u201cgastric precancerous lesions.\u201d Studies were included if they assessed the accuracy of the serum panel test for the diagnosis of atrophic gastritis using histology according to the updated Sydney System as reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty studies with a total of 4241 subjects assessed the performance of serum panel test for the diagnosis of atrophic gastritis regardless of the site in the stomach. The summary sensitivity was 74.7% (95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ), 62.0\u201084.3) and the specificity was 95.6% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 92.6\u201097.4). With a prevalence of atrophic gastritis of 27% (median prevalence across the studies), the negative predictive value was 91%. Few studies with small sample size assessed the performance of the test in detecting the site of atrophic gastritis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The combination of pepsinogen, gastrin\u201017 and anti\u2010\n                      <jats:italic>H. pylori<\/jats:italic>\n                      antibodies serological assays appears to be a reliable tool for the diagnosis of atrophic gastritis. This test may be used for screening subjects or populations at high risk of gastric cancer for atrophic gastritis; however, a cost\u2010effectiveness analysis is needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.14248","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T03:52:38Z","timestamp":1502077958000},"page":"657-667","source":"Crossref","is-referenced-by-count":175,"title":["Systematic review with meta\u2010analysis: diagnostic performance of the combination of pepsinogen, gastrin\u201017 and anti\u2010\n                    <i>Helicobacter pylori<\/i>\n                    antibodies serum assays for the diagnosis of atrophic gastritis"],"prefix":"10.1111","volume":"46","author":[{"given":"R. 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