{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:56:41Z","timestamp":1775854601306,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tissue transglutaminase (<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content>) immunoglobulin A (IgA) testing is a sensitive adjunct to the diagnosis of coeliac disease. The threshold for positivity was developed for diagnosis, with negative results reported as below the reference value (&lt;4\u00a0U\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate if an undetectable (<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> IgA&lt;1.2\u00a0U\/mL) is more predictive of healing compared to patients with negative but detectable serology (1.2\u20103.9\u00a0U\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of 402 treated coeliac disease patients seen at the Mayo Clinic with negative <jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> IgA values drawn within 1\u00a0month of duodenal biopsy between January 2009 and December 2015. The Corazza\u2010Villanacci score was used to assess mucosal healing. The presence of gastrointestinal symptoms was also collected. Logistic regression was used to assess the relationship of clinical variables with a normal biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with undetectable titres more frequently had normal duodenal histology compared to patients with detectable <jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> IgA levels (117\/240 vs. 53\/162; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.96; 1.292, 2.961). Asymptomatic patients more frequently had normal duodenum as compared to symptomatic patients (88\/163 vs. 82\/239; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=2.25; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.494, 3.377). Patients with undetectable serology and on a gluten\u2010free diet for \u22652\u00a0years were more likely to have no villous atrophy compared to patients with detectable serology (148\/192 vs. 55\/88; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=2.02; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.17, 3.49).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In subjects recovering from coeliac disease with negative <jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> IgA serology, an undetectable titre is associated with normal histology on follow\u2010up biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14250","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:08:38Z","timestamp":1502093318000},"page":"681-687","source":"Crossref","is-referenced-by-count":19,"title":["Undetectable negative tissue transglutaminase IgA antibodies predict mucosal healing in treated coeliac disease patients"],"prefix":"10.1111","volume":"46","author":[{"given":"H.","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"King","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Larson","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Division of Clinical Biochemistry and Immunology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. T.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-9090","authenticated-orcid":false,"given":"J. A.","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02086.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70007-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"},{"key":"e_1_2_7_5_1","first-page":"473","article-title":"Serological tests for celiac disease as indicators of long\u2010term compliance with the gluten\u2010free diet","volume":"23","author":"Nachman F","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07284.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200203000-00017"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001460"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12510"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0348"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.023978"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.08.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318221077e"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520500206277"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181615ca7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12970"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12164"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12621"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31598"},{"key":"e_1_2_7_21_1","first-page":"1295","article-title":"Celiac disease and immunoglobulin a deficiency: how effective are the serological methods of diagnosis?","volume":"9","author":"Kumar V","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13176"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3791-4"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:38:51Z","timestamp":1695476331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/apt.14250"],"URL":"https:\/\/doi.org\/10.1111\/apt.14250","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]}}}