{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:40:01Z","timestamp":1772160001106,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Government\u2019s Agreement for Medical Training and Research","award":["OLL-549221"],"award-info":[{"award-number":["OLL-549221"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether the epidemiology of ulcerative colitis (UC) has changed during recent decades is partly unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To depict temporal trends in the epidemiology and medical treatment of UC as well as the long\u2010term risk of progression in disease extent and colectomy, during 1963\u20102010.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were identified by evaluation of all medical records in the archive of the Colitis Clinic, \u00d6rebro University Hospital. Comparisons were made between three time periods, 1963\u20101975, 1976\u20101990 and 1991\u20102005.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The annual age\u2010standardised incidence increased from 3.5 to 18.5 per 100 000 during the study period (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). Correspondingly, the prevalence increased from 44 to 474 per 100 000 between 1965 and 2010. A higher proportion of males than females had extensive colitis at diagnosis (odds ratio: 1.55; 95% CI 1.17\u20102.05;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). The risk for progression in disease extent was 34.5% and 18.5% at 10 years, for patients with proctitis and left\u2010sided colitis, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). The use of 5\u2010aminosalicylates, within 10 years, rise from 79% to 92% between 1963\u20101975 and 1976\u20101990 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). Thiopurine use increased from 7% in 1976\u20101990 to 34% during 1991\u20102005 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). The colectomy rate at 10 years was 13.5% (95% CI 11.1%\u201015.8%), and the risk was lower among patients diagnosed in 1991\u20102005 compared to 1963\u20101975 (adjusted hazard ratio: 0.61; 95% CI 0.39\u20100.94;\n                      <jats:italic>P<\/jats:italic>\n                      = .02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence and prevalence of UC increased over time, and the observed prevalence in 2010 is among the highest reported. In parallel, a decrease in colectomy rates was observed during the most recent decades, potentially reflecting improved medical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.14268","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T22:26:42Z","timestamp":1503008802000},"page":"748-757","source":"Crossref","is-referenced-by-count":60,"title":["Changes in medical management and colectomy rates: a population\u2010based cohort study on the epidemiology and natural history of ulcerative colitis in \u00d6rebro, Sweden, 1963\u20102010"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-383X","authenticated-orcid":false,"given":"C.","family":"Eriksson","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics School of Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"Unit of Biostatistics Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rundquist","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhulina","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Henriksson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics School of Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Department of Epidemiology and Public Health University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Halfvarson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.063"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.309"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20029"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2010.03.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1962.tb07204.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90202-V"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209000168"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509093233"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21695"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.02.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1047792"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609004876"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.3.329"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.74"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.45"},{"key":"e_1_2_7_19_1","first-page":"1858","article-title":"Cumulative incidence and risk factors for hospitalization and surgery in a population\u2010based cohort of ulcerative colitis","volume":"19","author":"Samuel S","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.333"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20036"},{"key":"e_1_2_7_22_1","unstructured":"Statistics Sweden.Tables on the population in Sweden.http:\/\/www.scb.se\/be0101-en(accessed January 20 2016)."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.07.006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091339"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304636"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1093167"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471445428"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx055"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108998572"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0016-5085(81)80021-2","article-title":"Incidence rates of ulcerative colitis and Crohn's disease in fifteen areas of the United States","volume":"81","author":"Garland CF","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536701"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12086"},{"key":"e_1_2_7_34_1","unstructured":"Statistics Sweden Living Conditions Report no 114: Use of alcohol and tobacco 2007."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/15.5.404"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14063"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802600961"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.041"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305607"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv129"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1200141"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.068809"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13017"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04023.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.3780050102"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9350-y"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.117.2.292"},{"key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/00365521.1976.12097085","article-title":"The diagnosis of colitis by colonoscopy with biopsy and X\u2010ray examination. A blind comparative study","volume":"11","author":"Myren J","year":"1976","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_7_49_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0300-5089(21)00798-7","article-title":"Colonoscopy in inflammatory bowel disease","volume":"7","author":"Williams CB","year":"1978","journal-title":"Clin Gastroenterol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T20:34:50Z","timestamp":1695414890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/apt.14268"],"URL":"https:\/\/doi.org\/10.1111\/apt.14268","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.729083544.793549046","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}