{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:15:55Z","timestamp":1757780155630,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001009","name":"Bristol-Myers Squibb Foundation","doi-asserted-by":"publisher","award":["AI452\u2010104"],"award-info":[{"award-number":["AI452\u2010104"]}],"id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection is the leading cause of cirrhosis and hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) in the United States (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>) and an emerging cause in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the clinical characteristics of hepatitis C patients in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> and China, and factors influencing disease stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study of 2 cohorts of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> patients recruited at 1 site in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> and 3 sites in China. Standardised questionnaire on risk factors and medical history were used and diagnosis of cirrhosis and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> was based on pre\u2010defined criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand nine hundred and fifty seven patients (1000 <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> and 957 China) were enrolled. <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> patients were more likely to be men (61.4% vs 48.5%), older (median age 57 vs 53 years), obese (38.4% vs 16.8%) and diabetic (21.8% vs 10.8%). A significantly higher per cent of <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> patients had cirrhosis (38.2% vs 16.0%) and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> (14.1% vs 2.7%). Investigator estimated time at infection in <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> was 10 years earlier than in Chinese patients but <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> patients were more likely to have advanced disease even after stratifying for duration of infection. Study site in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>, older age, truncal obesity, diabetes and prior <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment were significant predictors of advanced disease on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> patients in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> had more advanced liver disease than those in China. We speculate that underlying fatty liver disease may be a major contributor to this difference, and management of glycometabolic abnormalities should occur in parallel with anti\u2010viral therapy to achieve optimal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14273","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T10:12:36Z","timestamp":1503396756000},"page":"731-740","source":"Crossref","is-referenced-by-count":22,"title":["The higher prevalence of truncal obesity and diabetes in American than Chinese patients with chronic hepatitis C might contribute to more rapid progression to advanced liver disease"],"prefix":"10.1111","volume":"46","author":[{"given":"H.","family":"Rao","sequence":"first","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine University of Michigan Health System Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine University of Michigan Health System Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Feng","sequence":"additional","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lin","sequence":"additional","affiliation":[{"name":"The Molecular and Behavioral Neuroscience Institute University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fei","sequence":"additional","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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