{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:42:56Z","timestamp":1790034176078,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DK007634"],"award-info":[{"award-number":["T32DK007634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK090073"],"award-info":[{"award-number":["K23DK090073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data describe the long\u2010term efficacy of dietary elimination in eosinophilic oesophagitis (EoE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the long\u2010term outcomes of food elimination diets for treatment of adults with EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study at our centre analysing all EoE patients receiving a food elimination diet without concomitant steroids. Baseline data were abstracted using standardised collection forms. Follow\u2010up data from a mean 24.9\u2010month period were collected for patients with a histological response to a food elimination diet during and after food reintroduction. The main outcomes were symptomatic, endoscopic and histological responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 52 patients, 18 received a 6\u2010food food elimination diet, 32 received targeted diet, and two received a 6\u2010food food elimination diet with targeted elimination. There were 21 (40%) patients with an initial histological response. Responders reported less dysphagia after treatment (95% baseline vs 11%; <jats:italic>P<\/jats:italic> = .001) and at the end of follow\u2010up (95% baseline vs 33%; <jats:italic>P<\/jats:italic> = .008). Significant and durable endoscopic improvements were recorded at the same time points: Endoscopic reference score: 3.2 vs 0.7; <jats:italic>P<\/jats:italic> = .001; and 3.2 vs 1.7; <jats:italic>P<\/jats:italic> = .06. Histological findings improved after the most restrictive diet in responders (49.8 vs 4.1 eosinophils per high\u2010power field; <jats:italic>P<\/jats:italic> = .001) and remained suppressed in the 10 initial responders maintaining compliance at the end of follow\u2010up (5.2 eosinophils per high\u2010power field).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among EoE patients responding to a food elimination diet and remaining adherent, maintenance dietary therapy produced durable long\u2010term symptomatic, endoscopic and histological disease control. These long\u2010term data confirm that a food elimination diet is an effective maintenance treatment option in select adults with EoE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14290","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T16:42:44Z","timestamp":1504716164000},"page":"836-844","source":"Crossref","is-referenced-by-count":90,"title":["Food elimination diets are effective for long\u2010term treatment of adults with eosinophilic oesophagitis"],"prefix":"10.1111","volume":"46","author":[{"given":"C. C.","family":"Reed","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. T.","family":"Koutlas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-5647","authenticated-orcid":false,"given":"N. J.","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1101","authenticated-orcid":false,"given":"E. 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