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Full\u2010length articles were selected for review, and a secondary bibliography was developed. The discovery process was repeated, and a tertiary bibliography was identified. The number of abstracts reviewed was 2830, and the number of full\u2010length articles reviewed exceeded 150.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Risk\u2010laden allelic variants outside the major histocompatibility complex (<jats:italic>rs3184504, r36000782<\/jats:italic>) are being identified by genome\u2010wide association studies, and their gene products are potential therapeutic targets. Epigenetic changes associated with environmental cues can enhance the transcriptional activity of genes, and chromatin re\u2010structuring and antagonists of noncoding molecules of ribonucleic acid are feasible interventions. The intestinal microbiome is a discovery field for microbial products and activated immune cells that may translocate to the periphery and respond to manipulation. Epidemiological studies and controlled interview\u2010based surveys may implicate environmental and xenobiotic factors that warrant evidence\u2010based changes in lifestyle, and site\u2010directed molecular and cellular interventions promise to change the paradigm of treatment from one of blanket immunosuppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Advances in genetics, epigenetics, pathophysiology, epidemiology, and site\u2010directed molecular and cellular interventions constitute the next generation of transformative advances in autoimmune hepatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14324","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T11:24:40Z","timestamp":1505301880000},"page":"920-937","source":"Crossref","is-referenced-by-count":21,"title":["Review article: next\u2010generation transformative advances in the pathogenesis and management of autoimmune hepatitis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-3065","authenticated-orcid":false,"given":"A. 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