{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:27:15Z","timestamp":1786408035234,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonalcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) is a leading cause of chronic liver disease in the US. Understanding the epidemiology of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, with specific focus on individuals with hepatic fibrosis is important to guide healthcare resource planning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate prevalence and predictors of hepatic fibrosis among US adults with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study using data from the updated 2011\u20102014 National Health and Nutrition Examination Survey, a national, stratified, multistage sampling survey of non\u2010institutionalised US adults age \u2265 20. <jats:styled-content style=\"fixed-case\">METAVIR<\/jats:styled-content> F2 or greater fibrosis among individuals with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> was assessed using <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> to Platelet Ratio Index (<jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>) score &gt; 0.7. <jats:styled-content style=\"fixed-case\">METAVIR<\/jats:styled-content> F3 or greater fibrosis was assessed using <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> fibrosis score (<jats:styled-content style=\"fixed-case\">NFS<\/jats:styled-content>) &gt; 0.676 and <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 score &gt; 3.25. Multivariate logistic regression models evaluated for predictors of fibrosis among individuals with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall prevalence of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> among US adults was 21.9% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 20.6\u201023.3), representing 51.6 million adults. Among individuals with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, we observed a 23.8% prevalence of \u2265F2 fibrosis, representing 12.2 million individuals, and we observed a 2.3%\u20109.7% prevalence of \u2265F3 fibrosis, representing as many as 5.0 million adults. On multivariate regression analyses, increasing age, obesity and concurrent diabetes mellitus were associated with increased risk of \u2265F3 fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> represents a major healthcare burden among US adults with as many as 5 million adults estimated to have <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> with \u2265F3 fibrosis. Age and the components of the metabolic syndrome are independently associated with higher risk of fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14327","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T11:52:40Z","timestamp":1505476360000},"page":"974-980","source":"Crossref","is-referenced-by-count":92,"title":["Significant burden of nonalcoholic fatty liver disease with advanced fibrosis in the US: a cross\u2010sectional analysis of 2011\u20102014 National Health and Nutrition Examination Survey"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-2806","authenticated-orcid":false,"given":"R. 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