{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:01:25Z","timestamp":1776866485446,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The frequency of coeliac disease (CD) has been on the rise over the past decades, especially in Western Europe, but current trends are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To research the recent temporal changes in the incidence of adult, biopsy\u2010verified coeliac disease and dermatitis herpetiformis (DH) in Finland, a country with a high frequency of coeliac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All coeliac disease and DH cases diagnosed at age 20\u201079 years during 2005\u20102014 were retrieved from a nationwide database documenting all applicants for monthly compensation to cover the extra cost of maintaining a gluten\u2010free diet. This benefit is granted on the basis of histology, not socioeconomic status. Temporal trends in the annual incidences were estimated using Poisson regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total incidence of coeliac disease decreased from 33\/100 000 during the years 2005\u20102006 to 29\/100 000 during 2013\u20102014. The mean annual incidence of coeliac disease was nearly twice as high among women as among men, 42 vs 22 per 100 000, respectively. For middle\u2010 and old\u2010aged women, the average rate of decrease in incidence was 4.8% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.9\u20105.7) per year and for men 3.0% (1.8\u20104.1) (<jats:italic>P<\/jats:italic> for linear trend &lt;.001, for both). Similarly, the annual incidence of DH declined. For young adults, the rate of change remained low and nonsignificant throughout the period 2005\u20102014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the awareness of coeliac disease has increased during the past decades, the incidence of biopsy\u2010verified diagnoses is not increasing, which suggests that exposure to yet unidentified triggering factors for coeliac disease has plateaued among the Finnish adult population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14335","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T09:06:42Z","timestamp":1505984802000},"page":"1085-1093","source":"Crossref","is-referenced-by-count":29,"title":["Declining trend in the incidence of biopsy\u2010verified coeliac disease in the adult population of Finland, 2005\u20102014"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6909-3178","authenticated-orcid":false,"given":"L. J.","family":"Virta","sequence":"first","affiliation":[{"name":"Research Department The Social Insurance Institution of Finland Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-3688","authenticated-orcid":false,"given":"M. M.","family":"Saarinen","sequence":"additional","affiliation":[{"name":"Departments of Public Health and Child Neurology University of Turku and Turku University Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-8415","authenticated-orcid":false,"given":"K.\u2010L.","family":"Kolho","sequence":"additional","affiliation":[{"name":"Children\u2032s Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90181-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1222450"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.2.206"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.6.517"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.4.669"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12373"},{"key":"e_1_2_7_9_1","first-page":"485","article-title":"Burden of celiac disease in Europe: a review of its childhood and adulthood prevalence and incidence as of September 2014","volume":"26","author":"Altobelli E","year":"2014","journal-title":"Ann Ig"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcgh.2003.50004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04150.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.130"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.915054"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.55"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl061"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012030-00013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328350f888"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609009152"},{"key":"e_1_2_7_19_1","first-page":"20","article-title":"An epidemiologic survey of celiac disease in the Terni area (Umbria, Italy) in 2002\u20102010","volume":"53","author":"Angeli G","year":"2012","journal-title":"J Prev Med Hyg"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.60"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10385.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000212618.12455.a8"},{"key":"e_1_2_7_23_1","unstructured":"Official Statistics of Finland.Population structure.www.stat.fi"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.00187.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076163"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520903030795"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.05.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03502.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02967.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04110.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01740.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.057"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03462.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021956200382"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03227.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-105"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9258-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90929-7"},{"key":"e_1_2_7_40_1","unstructured":"Suomalaisen L\u00e4\u00e4k\u00e4riseuran Duodecimin; Suomen Gastroenterologiayhdistys r.y:n. Asettama Ty\u00f6ryhm\u00e4 [Update on Current Care guidelines: coeliac disease]. Duodecim.2011;127:296\u2010297. Review. Finnish."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12970"},{"key":"e_1_2_7_42_1","unstructured":"LUKE Tilastotietokanta. http:stadb.luke.fi. Accessed April 12 2017."},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23305"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.09.018"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.10.007"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5103975"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1092576"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:32:46Z","timestamp":1695479566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,21]]},"references-count":46,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/apt.14335"],"URL":"https:\/\/doi.org\/10.1111\/apt.14335","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,21]]}}}