{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:38:29Z","timestamp":1792319909555,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG034676"],"award-info":[{"award-number":["R01AG034676"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton pump inhibitors (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) are inconsistently associated with osteoporotic fractures. Barrett's oesophagus (BO) patients are treated with high <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> doses for prolonged periods, but there are limited data on the incidence of osteoporosis and fractures in this group pf patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To estimate the incidence of (and risk factors for) low bone mass (osteoporosis and\/or osteopenia) related fractures in a population\u2010based BO cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All subjects with BO and a diagnosis of osteoporosis and fractures were identified using Rochester Epidemiology Project resources. The incidence rates of all and osteoporotic fractures in these subjects were compared to an age\u2010 and gender similar population in Olmsted County to determine standardised incidence ratios (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>). Predictors were assessed using Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and twenty\u2010one patients were included (median [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>] age 61 [52, 72]\u00a0years; 398 [76%] men) of whom 113 (21.7%) had fractures, and 46 (8.8%) had osteoporotic fractures. The incidence of all fractures and osteoporotic fractures was comparable to that of an age\u2010 and gender\u2010matched population (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content> 1.09; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.92\u20101.29: <jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content> 1.05; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.85\u20101.29). <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> use, dose or duration of use was not associated with osteoporotic fracture risk (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.87; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.12\u20106.39). Independent risk factors for osteoporotic fractures included older age, female gender and higher co\u2010morbidity index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of osteoporotic fractures was not increased in BO patients compared to the general population. In addition, <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> use was not associated with increased fracture risk regardless of the duration of therapy or dose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14345","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T08:02:34Z","timestamp":1507190554000},"page":"1094-1102","source":"Crossref","is-referenced-by-count":14,"title":["Incidence and predictors of osteoporotic fractures in patients with Barrett's oesophagus: a population\u2010based nested case\u2010control study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-3148","authenticated-orcid":false,"given":"S.","family":"Kumar","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Drake","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism &amp; Diabetes Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Schleck","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-1420","authenticated-orcid":false,"given":"P. G.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2012.07.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2015.02.010"},{"key":"e_1_2_7_4_1","first-page":"989","article-title":"Successful elimination of reflux symptoms does not insure adequate control of acid reflux in patients with Barrett's esophagus","volume":"89","author":"Katzka DA","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.24.2947"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.8.951"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.055"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.071330"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.11.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9170-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1243"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.113"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3365-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556841"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01352010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488608785699414"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900325"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq482"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.130"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.362"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610100102"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070214"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2257"},{"key":"e_1_2_7_27_1","unstructured":"Densitometry TISfC.Official positions of the international society for clinical densitometry. West Hartford CT: The International Society for Clinical Densitometry;2007."},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00003086-198103000-00008","article-title":"Epidemiologic features of pelvic fractures","volume":"155","author":"Melton LJ","year":"1981","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_29_1","first-page":"24","article-title":"Epidemiologic features of humeral fractures","volume":"168","author":"Rose SH","year":"1982","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050050"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050073"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2072"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0742-8"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1556"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:32:51Z","timestamp":1695479571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":33,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/apt.14345"],"URL":"https:\/\/doi.org\/10.1111\/apt.14345","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,5]]}}}