{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:05:27Z","timestamp":1792670727177,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The amino sulphonic acid taurine reduces oxidative endoplasmatic reticulum stress and inhibits hepatic stellate cell activation, which might lead to reduction of portal pressure in cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the haemodynamic effects of taurine supplementation in patients with cirrhosis and varices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with hepatic venous pressure gradient (\n                      <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>\n                      ) \u226512\u00a0mm Hg were included in this prospective proof of concept study. Concomitant nonselective beta\u2010blockers therapy was not allowed. Patients received either 4\u00a0weeks of oral taurine (6\u00a0g\/day), or placebo, prior to evaluation of\n                      <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>\n                      response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty patients were screened and 22 included in the efficacy analysis (12 taurine\/10 placebo; 64% male, mean age: 52\u00a0\u00b1\u00a011\u00a0years, Child A: 9%, B:64%, C:27%, ascites:68%).<\/jats:p>\n                    <jats:p>\n                      In the taurine group, mean\n                      <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>\n                      dropped from 20\u00a0mm Hg (\u00b14) at baseline to 18\u00a0mm Hg (\u00b14) on day 28 (mean relative change: \u221212%,\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      .0093). In the placebo group, mean\n                      <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>\n                      increased from 20 mm Hg (\u00b15) at baseline to 21\u00a0mm Hg (\u00b15) on day 28 (mean relative change:+2%,\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      .4945). Taurine had no significant effects on systemic haemodynamics. Seven of 12 patients (58%) on taurine achieved a\n                      <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>\n                      response &gt;10%, compared to none in the placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0\n                      <jats:italic>=<\/jats:italic>\n                      \u00a0.0053). In a multivariate linear model,\n                      <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>\n                      reduction was significantly larger in the taurine group compared to placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0091 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0109 for absolute and relative change respectively). Treatment\u2010related adverse events included gastrointestinal discomfort and fatigue, and were usually mild and comparable between treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taurine is safe and may reduce portal pressure in cirrhotic patients. More studies on the underlying mechanisms of action and long\u2010term effects of taurine supplementation are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.14377","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T10:34:07Z","timestamp":1509705247000},"page":"86-94","source":"Crossref","is-referenced-by-count":45,"title":["Randomised clinical study: the effects of oral taurine 6g\/day vs placebo on portal hypertension"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-096X","authenticated-orcid":false,"given":"R.","family":"Schwarzer","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Laboratory Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna 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