{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:03:48Z","timestamp":1783796628776,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the close relationship between primary sclerosing cholangitis (<jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>) and inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>), the association between colectomy and the prognosis of <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore whether colectomy prior to <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010diagnosis is associated with transplant\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide cohort study in Sweden including all patients aged 18 to 69 years in whom both <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> was diagnosed between 1987 and 2014 was undertaken. Each patient was followed from date of both <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> diagnoses until liver transplantation or death, or 31 December 2014. Patients with colon in situ, and colectomy prior to <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010diagnosis were compared. Survival analyses were performed using the Kaplan\u2010Meier method and multivariable Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2594 <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients, 205 patients were treated with colectomy before <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010diagnosis. During follow\u2010up, liver transplantations were performed in 327 patients and 509 died. The risk of liver transplantation or death was lower in patients treated with colectomy prior to <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010diagnosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.71, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.53\u20100.95) than in patients with colon in situ. Male gender, longer time between <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010diagnosis and older age were all associated with an increased risk of liver transplantation or death. Colectomy after <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010diagnosis was however not associated with an increased risk of liver transplantation or death during long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients, colectomy prior to <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010diagnosis is associated with a decreased risk of liver transplantation or death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14393","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T10:32:45Z","timestamp":1508841165000},"page":"238-245","source":"Crossref","is-referenced-by-count":72,"title":["Colectomy prior to diagnosis of primary sclerosing cholangitis is associated with improved prognosis in a nationwide cohort study of 2594 <scp>PSC<\/scp>\u2010<scp>IBD<\/scp> patients"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5112-8894","authenticated-orcid":false,"given":"C.","family":"Nordenvall","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"},{"name":"Division of Coloproctology Center for Digestive Disease Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ol\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Karolinska Institutet Clinical Epidemiology Unit Stockholm Sweden"},{"name":"Department of Pediatric Gastroenterology and Nutrition Sachs\u2019 Children's Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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