{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:40Z","timestamp":1787013880822,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK84413\u20104"],"award-info":[{"award-number":["K23DK84413\u20104"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK007130"],"award-info":[{"award-number":["T32 DK007130"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK097317"],"award-info":[{"award-number":["R01DK097317"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["2P30DK052574"],"award-info":[{"award-number":["2P30DK052574"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Genetic polymorphisms in G\u2010protein beta\u20103 subunit (\n GN<\/jats:styled-content>\n \u03b23) and beta\u20102 adrenergic receptor (\n ADRB<\/jats:styled-content>\n 2) are associated with pain and gut hypersensitivity, which can overlap with gastroesophageal reflux disease (\n GERD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To evaluate relationships between single nucleotide polymorphisms (\n SNP<\/jats:styled-content>\n s) within\n GN<\/jats:styled-content>\n \u03b23 and\n ADRB<\/jats:styled-content>\n 2 systems, and reflux symptom burden,\n GERD<\/jats:styled-content>\n phenotypes from ambulatory reflux monitoring, and quality of life.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Symptomatic adults undergoing ambulatory reflux testing were recruited and phenotyped based on acid burden and symptom reflux association; major oesophageal motor disorders and prior foregut surgery were exclusions. A comparison asymptomatic control cohort was also identified. Subjects and controls completed questionnaires assessing symptom burden on visual analog scales, short\u2010form health survey\u201036 (\n SF<\/jats:styled-content>\n \u201036), and Beck Anxiety and Depression Inventories (\n BAI<\/jats:styled-content>\n and\n BDI<\/jats:styled-content>\n ). Genotyping was performed from saliva samples; 6\n SNP<\/jats:styled-content>\n s selected from each of the two genes of interest were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Saliva from 151 study subjects (55.3 \u00b1 1.2 years, 63.6% F) and 60 control subjects (50.9 \u00b1 2.2 years, 66.7%) had sufficient genetic material for genotyping. Study subjects had higher symptom burden, worse total and physical health, and higher anxiety scores compared to controls (\n P<\/jats:italic>\n \u2264 .002). Tested\n SNP<\/jats:styled-content>\n s within\n ADRB<\/jats:styled-content>\n 2 were similar between study subjects and controls (\n P<\/jats:italic>\n > .09). Study subjects with recessive alleles in 3\n GN<\/jats:styled-content>\n \u03b23\n SNP<\/jats:styled-content>\n s (Rs2301339, Rs5443, and Rs5446) had worse symptom severity (\n P<\/jats:italic>\n = .011), worse mental health (\n P<\/jats:italic>\n = .03), and higher depression scores (\n P<\/jats:italic>\n = .005) despite no associations with\n GERD<\/jats:styled-content>\n phenotypes or reflux metrics.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Genetic variation within\n GN<\/jats:styled-content>\n \u03b23 predicts oesophageal symptom burden and affect, but not oesophageal acid burden or symptom association with reflux episodes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.14414","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T02:16:43Z","timestamp":1510885003000},"page":"289-297","source":"Crossref","is-referenced-by-count":14,"title":["Genetic risk factors for perception of symptoms in\n GERD<\/scp>\n : an observational cohort study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7214-5901","authenticated-orcid":false,"given":"A.","family":"Patel","sequence":"first","affiliation":[{"name":"Duke University School of Medicine Durham VA Medical Center Durham NC USA"},{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hasak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. D.","family":"Nix","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-199X","authenticated-orcid":false,"given":"G. S.","family":"Sayuk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-5191","authenticated-orcid":false,"given":"R. D.","family":"Newberry","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. P.","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.342"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.07.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00427.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.1.7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12838"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.139"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12378"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12745"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.63"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.1101982"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13067"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.7.738"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90815-X"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05066.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/35015718"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg151"},{"key":"e_1_2_7_24_1","first-page":"187","article-title":"The essentiality of reporting Hardy\u2010Weinberg equilibrium calculations in population\u2010based genetic association studies","volume":"17","author":"Namipashaki A","year":"2015","journal-title":"Cell J"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201410"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.012"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12313"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01060.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1085"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03326.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13017"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12923"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.129"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12396"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170994"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.09.039"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110376683"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T07:05:02Z","timestamp":1694675102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,17]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/apt.14414"],"URL":"https:\/\/doi.org\/10.1111\/apt.14414","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,17]]}}}