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Extra\u2010oesophageal manifestations of<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>gained increasing attention over the last decade, especially respiratory disorders, because of the prevalent co\u2010occurrence with<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>. The role of<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>in the pathogenesis of respiratory disorders has become a topic of intense discussion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To provide an overview of the current knowledge on the role of<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>in asthma and chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed was searched for relevant articles using the keywords:<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>, asthma,<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, prevalence, treatment. Case reports were excluded, only English language articles were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimates for the prevalence of<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>in asthma range from 30% to 90%, compared to an average of 24% in controls. In<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>patients, the prevalence of<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>ranges from 19% to 78% compared to an average of 18% in controls. These data indicate an increased prevalence of<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>in patients with asthma and<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, although causality is not established and<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>treatment yielded inconsistent effects. Literature supports<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>as a risk factor for<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>\u2010exacerbations and a predictor of the \u2018frequent\u2010exacerbator\u2019\u2013phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the high prevalence of<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>in asthma and<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, a causal link is lacking. The results of anti\u2010reflux therapy on pulmonary outcome are inconsistent and contradictory. Future studies will need to identify subgroups of asthmatics and<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>patients that may benefit from anti\u2010reflux therapy (nocturnal or silent reflux).<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14416","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:43:49Z","timestamp":1511977429000},"page":"176-191","source":"Crossref","is-referenced-by-count":84,"title":["Review article: gastro\u2010oesophageal reflux disease in asthma and chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"47","author":[{"given":"C.","family":"Broers","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal Disorders (TARGID) KU Leuven Leuven 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