{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:27:48Z","timestamp":1792664868834,"version":"4.5.0"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Atrophic gastritis and intestinal metaplasia are premalignant conditions for gastric cancer. Their reversibility by\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication remains controversial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the reversibility of atrophic gastritis and intestinal metaplasia by\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication with long\u2010term follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      598 subjects were prospectively enrolled and followed for up to 10 years. They were categorised as\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010negative (n = 65),\n                      <jats:italic>H. pylori<\/jats:italic>\n                      non\u2010eradicated (n = 91), and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010eradicated (n = 442). Histological assessment was performed for antrum and corpus by Sydney classification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histological follow\u2010up was performed regularly at 1, 2, 3\u20104 and \u22655 years, with mean follow\u2010up of 1.07 \u00b1 0.21, 2.29 \u00b1 0.83, 3.93 \u00b1 1.02, and 6.45 \u00b1 1.28 years, respectively. Atrophic gastritis in antrum and corpus gradually and significantly (both\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05 for all timepoints) improved only in the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010eradicated group compared to that at baseline. Significant difference in atrophic gastritis between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010eradicated and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010negative groups disappeared from 1\u2010year follow\u2010up. Similarly, intestinal metaplasia in antrum and corpus improved significantly (both\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05 for all timepoints) only in the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010eradicated group in comparison with that at baseline. Significant difference in intestinal metaplasia between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010eradicated and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010negative groups disappeared from \u22655 years of follow\u2010up in the antrum and from 3 years of follow\u2010up in the corpus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication may be a preventative strategy for intestinal\u2010type gastric cancer by regression of atrophic gastritis and intestinal metaplasia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.14424","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T12:44:34Z","timestamp":1511959474000},"page":"380-390","source":"Crossref","is-referenced-by-count":190,"title":["Reversibility of atrophic gastritis and intestinal metaplasia after\n                    <i>Helicobacter pylori<\/i>\n                    eradication \u2010 a prospective study for up to 10 years"],"prefix":"10.1111","volume":"47","author":[{"given":"Y.\u2010J.","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoungnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-0406","authenticated-orcid":false,"given":"N.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoungnam South Korea"},{"name":"Department of Internal Medicine and Institute of Liver Research Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seoungnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Statistics in Medical Research Collaborating Center Seoul National University Bundang Hospital Seoungnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. J.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoungnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoungnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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