{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:08:01Z","timestamp":1790460481982,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","award":["101679"],"award-info":[{"award-number":["101679"]}],"id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Validated diagnostic tools that are accurate, cost effective and acceptable to patients are required for disease stratification and monitoring in NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Aims<\/jats:title>To investigate the performance and cost of multiparametric MRI<\/jats:styled-content> alongside existing biomarkers in the assessment of NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Adult patients undergoing standard of care liver biopsy for NAFLD<\/jats:styled-content> were prospectively recruited at two UK<\/jats:styled-content> liver centres and underwent multiparametric MRI<\/jats:styled-content>, blood sampling and transient elastography withing 2\u00a0weeks of liver biopsy. Non\u2010invasive markers were compared to histology as the gold standard.<\/jats:p><\/jats:sec>Results<\/jats:title>Data were obtained in 50 patients and 6 healthy volunteers. Corrected T1 (cT<\/jats:styled-content>1) correlated with NAFLD<\/jats:styled-content> activity score (\u03c1\u00a0=\u00a00.514, P<\/jats:italic>\u00a0<\u00a0.001). cT<\/jats:styled-content>1, enhanced liver fibrosis (ELF<\/jats:styled-content>) test and liver stiffness differentiated patients with simple steatosis and NASH<\/jats:styled-content> with AUROC<\/jats:styled-content> (95% CI<\/jats:styled-content>) of 0.69 (0.50\u20100.88), 0.87 (0.77\u20100.79) and 0.82 (0.70\u20100.94) respectively and healthy volunteers from patients with AUROC<\/jats:styled-content> (95% CI<\/jats:styled-content>) of 0.93 (0.86\u20101.00), 0.81 (0.69\u20100.92) and 0.89 (0.77\u20101.00) respectively. For the risk stratification of NAFLD<\/jats:styled-content>, multiparametric MRI<\/jats:styled-content> could save \u00a3150,218 per 1000 patients compared to biopsy. Multiparametric MRI<\/jats:styled-content> did not discriminate between individual histological fibrosis stages in this population (P<\/jats:italic>\u00a0=\u00a0.068).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Multiparametric MRI<\/jats:styled-content> accurately identified patients with steatosis, stratifies those with NASH<\/jats:styled-content> or simple steatosis and reliably excludes clinically significant liver disease with superior negative predictive value (83.3%) to liver stiffness (42.9%) and ELF<\/jats:styled-content> (57.1%). For the risk stratification of NAFLD<\/jats:styled-content>, multiparametric MRI<\/jats:styled-content> was cost effective and, combined with transient elastography, had the lowest cost per correct diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14469","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T07:59:28Z","timestamp":1514102368000},"page":"631-644","source":"Crossref","is-referenced-by-count":96,"title":["Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-7054","authenticated-orcid":false,"given":"P. 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