{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:34:02Z","timestamp":1789569242803,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The most common complication after ileal pouch anal anastomosis in up to 50% of patients is an acute pouchitis. The majority of patients respond to antibiotic treatment. However, 10%\u201015% develops chronic antibiotic\u2010dependent or refractory pouchitis which is usually hard to treat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effectiveness of vedolizumab in patients with chronic pouchitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with chronic antibiotic\u2010dependent or refractory pouchitis were treated with vedolizumab (300\u00a0mg at week 0, 2, 6 and 10) in 10 <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> centres and retrospectively registered. Data were recorded until week 14 of vedolizumab treatment. In total 20 patients (12 male, median age 43\u00a0years) were included for analysis. The effectiveness was measured using the Oresland Score (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) at week 2, 6, 10 and 14 and the pouch disease activity index (<jats:styled-content style=\"fixed-case\">PDAI<\/jats:styled-content>) at week 0 and 14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> declined from 6.8 (range 2\u201012) to 3.4 (range 0\u201011). Concordantly, the mean <jats:styled-content style=\"fixed-case\">PDAI<\/jats:styled-content> after 14\u00a0weeks of treatment dropped from 10 (range 5\u201018) to 3 (range 0\u201010). Only three patients reported moderate side effects. No serious side effects were recorded. In addition, symptomatic co\u2010medication such as loperamide and tincture of opium could be terminated in 8 out of 12 patients as well as antibiotic treatment could be stopped in 17 out of 19 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that vedolizumab could be an option in the treatment of patients with chronic, antibiotic\u2010dependent or refractory pouchitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14479","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T03:46:59Z","timestamp":1513741619000},"page":"581-587","source":"Crossref","is-referenced-by-count":78,"title":["Vedolizumab in the treatment of chronic, antibiotic\u2010dependent or refractory pouchitis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-1808","authenticated-orcid":false,"given":"F.","family":"B\u00e4r","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University Hospital Schleswig\u2010Holstein Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"K\u00fchbacher","sequence":"additional","affiliation":[{"name":"Asklepios Westklinikum Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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