{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:10:41Z","timestamp":1779923441996,"version":"3.53.1"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Direct\u2010acting antiviral (DAA<\/jats:styled-content>) regimens have shown high efficacy and tolerability for patients with HCV<\/jats:styled-content> genotype 1\/1b (GT<\/jats:styled-content>1\/1b) in clinical trials. However, robust real\u2010world evidence of interferon (IFN<\/jats:styled-content>)\u2010free DAA<\/jats:styled-content> treatment for HCV GT<\/jats:styled-content>1\u2010infected patients in Asia is still lacking.<\/jats:p><\/jats:sec>Aim<\/jats:title>To systematically review and meta\u2010analyse the effectiveness and tolerability of IFN<\/jats:styled-content>\u2010free DAA<\/jats:styled-content> therapy for HCV GT<\/jats:styled-content>1 infection in Asia.<\/jats:p><\/jats:sec>Methods<\/jats:title>We included studies that enrolled adult patients with HCV GT<\/jats:styled-content>1 infection in routine clinical practice in Asia, using IFN<\/jats:styled-content>\u2010free DAA<\/jats:styled-content> regimens, and reported sustained virological response (SVR<\/jats:styled-content>) after 12\/24\u00a0weeks end\u2010of\u2010treatment by 31 May 2017. The pooled SVR<\/jats:styled-content> rates were computed with a random\u2010effects model. Subgroup analysis and meta\u2010regression as previously registered in PROSPERO<\/jats:styled-content> were performed to determine how pre\u2010planned variables might have affected the pooled estimates.<\/jats:p><\/jats:sec>Results<\/jats:title>We included 41 studies from eight countries and regions, comprising of 8574 individuals. The pooled SVR<\/jats:styled-content> rates for GT<\/jats:styled-content>1 were 89.9% (95% CI 88.6\u201091.1, I<\/jats:italic>2<\/jats:sup>\u00a0=\u00a055.1%) with daclatasvir\/asunaprevir (DCV<\/jats:styled-content>\/ASV<\/jats:styled-content>) and 98.1% (95% CI 97.0\u201099.0, I<\/jats:italic>2<\/jats:sup>\u00a0=\u00a041.0%) with ledipasvir\/sofosbuvir\u00a0\u00b1\u00a0ribavirin (LDV<\/jats:styled-content>\/SOF<\/jats:styled-content>\u00a0\u00b1\u00a0RBV<\/jats:styled-content>). Baseline cirrhosis but not prior treatment history and age, attenuated the effectiveness of both regimens. Baseline resistance associated substitutions (RAS<\/jats:styled-content>s) severely attenuated SVR<\/jats:styled-content> of DCV<\/jats:styled-content>\/ASV<\/jats:styled-content> (65.4% vs 94.3%, P<\/jats:italic>\u00a0<\u00a00.001) and only minimally with LDV<\/jats:styled-content>\/SOF<\/jats:styled-content>\u00a0\u00b1\u00a0RBV<\/jats:styled-content> (94.5% vs 99.2%, P<\/jats:italic>\u00a0=\u00a00.003). Patients with renal dysfunction treated with DCV<\/jats:styled-content>\/ASV<\/jats:styled-content> showed a higher SVR<\/jats:styled-content> rate (93.9% vs 89.8%, P<\/jats:italic>\u00a0=\u00a00.046). Patients with hepatocellular carcinoma (HCC<\/jats:styled-content>) LDV<\/jats:styled-content>\/SOF<\/jats:styled-content>\u00a0\u00b1\u00a0RBV<\/jats:styled-content> achieved a lower SVR<\/jats:styled-content> than those without HCC<\/jats:styled-content> (94.1% vs 98.7%, P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>All oral DAA<\/jats:styled-content> treatment of HCV GT<\/jats:styled-content>1 resulted in high cure rates in Asian patients in routine clinical practice setting including elderly patients and those with end\u2010stage renal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14507","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T10:02:37Z","timestamp":1515751357000},"page":"550-562","source":"Crossref","is-referenced-by-count":49,"title":["Systematic review with meta\u2010analysis: effectiveness and tolerability of interferon\u2010free direct\u2010acting antiviral regimens for chronic hepatitis C genotype 1 in routine clinical practice in Asia"],"prefix":"10.1111","volume":"47","author":[{"given":"F.","family":"Ji","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center Palo Alto CA USA"},{"name":"Department of Infectious Diseases The Second Affiliated Hospital of Xi\u2019 an Jiaotong University Xi'an China"},{"name":"Shaanxi Provincial Clinical Research Center for Hepatic & Splenic Diseases The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. H.","family":"Yeo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-3967","authenticated-orcid":false,"given":"E.","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center Palo Alto CA USA"},{"name":"Department of General Internal Medicine Kyushu University Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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