{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:09:54Z","timestamp":1773047394725,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excessive amounts of bile acids entering the colon due to bile acid malabsorption cause chronic bile acid diarrhoea. Diagnosis is possible by measuring the retention fraction of orally ingested<jats:sup>75<\/jats:sup>Selenium homotaurocholic acid (Se<jats:styled-content style=\"fixed-case\">HCAT<\/jats:styled-content>). The knowledge of long\u2010term effects of medical treatment is sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe diarrhoea, adherence to treatment, treatment effects and quality of life in a large, well\u2010defined cohort of patients with bile acid diarrhoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective survey was performed among 594 patients with bile acid malabsorption verified by Se<jats:styled-content style=\"fixed-case\">HCAT<\/jats:styled-content>scans at our unit between 2003 and 2016. Questionnaires about medical history, diarrhoea, use of medication, and quality of life scores were mailed to all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 594 patients 377 (69%) responded. Among respondents, 121 (32%) had bile acid diarrhoea due to ileal disease or resection (type 1), 198 (52%) idiopathic bile acid diarrhoea (type 2) and 58 (16%) bile acid diarrhoea due to other non\u2010ileal disease, mainly cholecystectomy (type 3). At follow\u2010up, half of the patients, 184 (50%), reported improvement of diarrhoea. However, 273 patients (74%) still reported diarrhoea and 234 (62%) regularly used anti\u2010diarrhoeal medication. In spite of treatment, 235 (64%) considered reduced quality of life by diarrhoea and 184\u00a0(50%) reported that diarrhoea was unaltered or worse than before established diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Many patients with bile acid diarrhoea continue to have bothersome diarrhoea in spite of correct diagnosis and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14533","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T04:27:33Z","timestamp":1516854453000},"page":"951-957","source":"Crossref","is-referenced-by-count":42,"title":["Long\u2010term effect of medical treatment of diarrhoea in 377 patients with Se<scp>HCAT<\/scp>scan diagnosed bile acid malabsorption from 2003 to 2016; a retrospective study"],"prefix":"10.1111","volume":"47","author":[{"given":"B.","family":"Damsgaard","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Dalby","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5135-7435","authenticated-orcid":false,"given":"S. M. D.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Arveschough","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET\u2010centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Agnholt","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Dahlerup","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6530-6655","authenticated-orcid":false,"given":"S. P.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12684"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.08.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13227"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04081.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.7861\/clinmedicine.15-4-371","article-title":"Quantifying bile acid malabsorption helps predict response and tailor sequestrant therapy","volume":"15","author":"Orekoya O","year":"2015","journal-title":"Clin Med (Lond)"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2196\/resprot.4467"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.32"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.10.54"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.23"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309889"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12466"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.11.027"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2653-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-007-0054-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.68.798.272"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00388.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.15-6-536"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-5-412"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14397"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10377126"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750026047"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000541"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.remn.2016.08.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.04.024"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00121.2015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12999"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.08.004"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e32835e8989"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2016-000091"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T18:44:33Z","timestamp":1719773073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/apt.14533"],"URL":"https:\/\/doi.org\/10.1111\/apt.14533","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,24]]}}}