{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:48:03Z","timestamp":1788306483917,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> is an autoimmune biliary inflammatory disorder that is often associated with inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>), with 50%\u201075% of patients with <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> having coexisting <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>, most commonly ulcerative colitis. Currently, no medical therapies have been shown to improve the disease course or slow its progression. However, ongoing research has resulted in a growing interest in the use of antibiotics for treatment of <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>, of which vancomycin is the most studied. In this review, we summarise the current evidence on the use of vancomycin in <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> and comment on future research areas of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> literature search for articles on vancomycin, <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>, therapeutic options and microbiome was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two randomised clinical trials, three case series and two case reports were included in the study. These include uncontrolled data from at least 98 patients that include promising improvements in biochemistry and imaging. Optimal dosing regimens are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vancomycin is one of the most studied antibiotics used in the treatment of <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> with promising results. There is not currently sufficient evidence to support treatment recommendations. Further research is needed to establish if vancomycin is a <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14540","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T05:56:39Z","timestamp":1517982999000},"page":"886-895","source":"Crossref","is-referenced-by-count":72,"title":["Review article: the evidence that vancomycin is a therapeutic option for primary sclerosing cholangitis"],"prefix":"10.1111","volume":"47","author":[{"given":"J. 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