{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:14:51Z","timestamp":1790813691374,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labour Sciences Research Grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether direct\u2010acting anti\u2010viral therapy can reduce liver fibrosis and steatosis in patients with chronic hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate changes in liver stiffness and steatosis in patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> who received direct\u2010acting anti\u2010viral therapy and achieved sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 198 patients infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 1 or 2 who achieved <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> after direct\u2010acting anti\u2010viral therapy were analysed. Liver stiffness as evaluated by magnetic resonance elastography, steatosis as evaluated by magnetic resonance imaging\u2010determined proton density fat fraction (<jats:styled-content style=\"fixed-case\">PDFF<\/jats:styled-content>), insulin resistance, and laboratory data were assessed before treatment (baseline) and at 24 weeks after the end of treatment (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alanine aminotransferase and homeostatic model assessment\u2010insulin resistance levels decreased significantly from baseline to <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>24. Conversely, platelet count, which is inversely associated with liver fibrosis, increased significantly from baseline to <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>24. In patients with high triglyceride levels (\u2265150 mg\/dL), triglyceride levels significantly decreased from baseline to <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>24 (<jats:italic>P<\/jats:italic> = 0.004). The median (interquartile range) liver stiffness values at baseline and <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>24 were 3.10 (2.70\u20104.18) <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a and 2.80 (2.40\u20103.77) <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). The <jats:styled-content style=\"fixed-case\">PDFF<\/jats:styled-content> values at baseline and <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> 24 were 2.4 (1.7\u20103.4)% and 1.9 (1.3\u20102.8)% respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). In addition, 68% (19\/28) of patients with fatty liver at baseline (<jats:styled-content style=\"fixed-case\">PDFF<\/jats:styled-content> \u22655.2%; n = 28) no longer had fatty liver (<jats:styled-content style=\"fixed-case\">PDFF<\/jats:styled-content> &lt;5.2%) at <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Viral eradication reduces both liver stiffness and steatosis in patients with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> who received direct\u2010acting anti\u2010viral therapy (<jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>000017020).<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14554","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T10:42:41Z","timestamp":1518172961000},"page":"1012-1022","source":"Crossref","is-referenced-by-count":69,"title":["Viral eradication reduces both liver stiffness and steatosis in patients with chronic hepatitis C virus infection who received direct\u2010acting anti\u2010viral therapy"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"T.","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Radiology Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wakahata","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nakamuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control, and Prevention Hiroshima University Institute of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00004"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Global alert and response (GAR): hepatitis C. 2011 (January 26).http:\/\/www.who.int\/csr\/disease\/hepatitis\/whocdscsrlyo2003\/en\/index4.html. 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