{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:22:48Z","timestamp":1792383768684,"version":"4.4.0"},"reference-count":104,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS: PI10\/01827"],"award-info":[{"award-number":["FIS: PI10\/01827"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PI15\/00151"],"award-info":[{"award-number":["PI15\/00151"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004141","name":"Society of Gastrointestinal Radiologists","doi-asserted-by":"publisher","award":["2014_SGR_605"],"award-info":[{"award-number":["2014_SGR_605"]}],"id":[{"id":"10.13039\/100004141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["GLD17\/00273"],"award-info":[{"award-number":["GLD17\/00273"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic hepatitis C is considered a systemic disease because of extra\u2010hepatic manifestations. Neuroimaging has been employed in hepatitis C virus\u2010infected patients to find in\u00a0vivo evidence of central nervous system alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Systematic review and meta\u2010analysis of neuroimaging research in chronic hepatitis C treatment naive patients, or patients previously treated without sustained viral response, to study structural and functional brain impact of hepatitis C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> guidelines a database search was conducted from inception up until 1 May 2017 for peer\u2010reviewed studies on structural or functional neuroimaging assessment of chronic hepatitis C patients without cirrhosis or encephalopathy, with control group. Meta\u2010analyses were performed when possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final sample comprised 25 studies (magnetic resonance spectroscopy [N\u00a0=\u00a012], perfusion weighted imaging [N\u00a0=\u00a01], positron emission tomography [N\u00a0=\u00a03], single\u2010photon emission computed tomography [N\u00a0=\u00a04], functional connectivity in resting state [N\u00a0=\u00a01], diffusion tensor imaging [N\u00a0=\u00a02] and structural magnetic resonance imaging [N\u00a0=\u00a02]). The whole sample was of 509 chronic hepatitis C patients, with an average age of 41.5\u00a0years old and mild liver disease. A meta\u2010analysis of magnetic resonance spectroscopy studies showed increased levels of choline\/creatine ratio (mean difference [MD] 0.12, 95% confidence interval [CI] 0.06\u20100.18), creatine (MD 0.85, 95% CI 0.42\u20101.27) and glutamate plus glutamine (MD 1.67, 95% CI 0.39\u20102.96) in basal ganglia and increased levels of choline\/creatine ratio in centrum semiovale white matter (MD 0.13, 95% CI 0.07\u20100.19) in chronic hepatitis C patients compared with healthy controls. Photon emission tomography studies meta\u2010analyses did not find significant differences in <jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>11195 binding potential in cortical and subcortical regions of chronic hepatitis C patients compared with controls. Correlations were observed between various neuroimaging alterations and neurocognitive impairment, fatigue and depressive symptoms in some studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with chronic hepatitis C exhibit cerebral metabolite alterations and structural or functional neuroimaging abnormalities, which sustain the hypothesis of hepatitis C virus involvement in brain disturbances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14594","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T11:50:32Z","timestamp":1521114632000},"page":"1238-1252","source":"Crossref","is-referenced-by-count":15,"title":["Systematic review with meta\u2010analysis: neuroimaging in hepatitis C chronic infection"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-7894","authenticated-orcid":false,"given":"G.","family":"Oriolo","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology Hospital Clinic Institut d'Investigaci\u00f3 Biom\u00e8dica Arthur Pi I Sunyer (IDIBAPS) Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) University of Barcelona Barcelona Spain"},{"name":"Department of Medicine Institute of Neuroscience University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Egmond","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Hospital Clinic Institut d'Investigaci\u00f3 Biom\u00e8dica Arthur Pi I Sunyer (IDIBAPS) Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) University of Barcelona Barcelona Spain"},{"name":"Department of Medicine Institute of Neuroscience University of Barcelona Barcelona Spain"},{"name":"Department of Health and Clinical Psychology Faculty of Psychology Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Mari\u00f1o","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Clinic IDIBAPS Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades hep\u00e1ticas y digestivas, (CIBEREHD) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cavero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Hospital Clinic Institut d'Investigaci\u00f3 Biom\u00e8dica Arthur Pi I Sunyer (IDIBAPS) Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) University of Barcelona Barcelona Spain"},{"name":"Department of Medicine Institute of Neuroscience University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Navines","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Hospital Clinic Institut d'Investigaci\u00f3 Biom\u00e8dica Arthur Pi I Sunyer (IDIBAPS) Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) University of Barcelona Barcelona Spain"},{"name":"Department of Medicine Institute of Neuroscience University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zamarrenho","sequence":"additional","affiliation":[{"name":"Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento Faculdade de Medicina de Ribeir\u00e3o Preto \u2013 Universidade de S\u00e3o Paulo (USP) Ribeir\u00e3o Preto (SP) Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sol\u00e0","sequence":"additional","affiliation":[{"name":"Liver Unit Parc de Salut Mar Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pujol","sequence":"additional","affiliation":[{"name":"MRI Research Unit Department of Radiology Hospital del Mar, CIBERSAM Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bargallo","sequence":"additional","affiliation":[{"name":"Center of Diagnostic Image (CDIC) Hospital Clinic Magnetic Resonance Image Core Facility IDIBAPS Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Forns","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Clinic IDIBAPS Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades hep\u00e1ticas y digestivas, (CIBEREHD) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-4726","authenticated-orcid":false,"given":"R.","family":"Martin\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Hospital Clinic Institut d'Investigaci\u00f3 Biom\u00e8dica Arthur Pi I Sunyer (IDIBAPS) Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) University of Barcelona Barcelona Spain"},{"name":"Department of Medicine Institute of Neuroscience University of Barcelona Barcelona Spain"},{"name":"Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento Faculdade de Medicina de Ribeir\u00e3o Preto \u2013 Universidade de S\u00e3o Paulo (USP) Ribeir\u00e3o Preto (SP) Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.WHO Fact sheet on hepatitis C 2017.http:\/\/www.who.int\/mediacentre\/factsheets\/fs164\/en\/"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01919.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i8.2269"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2012.01591.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01612840701869239"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i19.2295"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12625"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00416.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v27n02_02"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617703960048"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.30688"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31257"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i29.3369"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00172-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i7.922"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2016.09.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000192083.41561.00"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/526519"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.19.10064-10068.2002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01890-08"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.36393"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1255725"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13514"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw676"},{"key":"e_1_2_8_26_1","first-page":"CD012143","article-title":"Direct\u2010acting antivirals for chronic hepatitis C","volume":"9","author":"Jakobsen JC","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.199356"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.69"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.06.009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666151215102420"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.10.010"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.7.1342"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2094"},{"key":"e_1_2_8_34_1","first-page":"235","article-title":"Biological mechanisms of depression following treatment with interferon for chronic hepatitis C: a critical systematic review","volume":"2016","author":"Machado MO","year":"2016","journal-title":"J Affect Disord"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12r07694"},{"key":"e_1_2_8_36_1","first-page":"1","article-title":"Functional connectivity alterations in patients with chronic hepatitis C virus infection: a multimodal MRI study","author":"Kharabian Masouleh S","year":"2016","journal-title":"J Viral Hepat"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/89.9.873"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_8_40_1","unstructured":"HigginsJ GreenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0(Higgins J Green S eds.) 2011.http:\/\/handbook.cochrane.org."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_42_1","first-page":"345","article-title":"Neuropsychiatric disorders and magnetic resonance spectroscopy in chronic hepatitis C patients","volume":"51","author":"Allah HMS","year":"2014","journal-title":"Egyptian J Neurol Psychiatry Neurosurg"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102214"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.008"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.11.029"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.217976"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05270-3"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.03.022"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01510.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-015-9752-3"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20635"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/179365"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000059"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080267"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.07.022"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12496"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.82"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.006"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011602"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2010.22.3.313"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i10.528"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22084"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13732"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110254"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.04.009"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12197"},{"key":"e_1_2_8_70_1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller AH","year":"2009","journal-title":"Psychiatry Interpers Biol Process"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.11.006"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2012.10.002"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.08.010"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.5.995"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2007.12.006"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i2.188"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.598136"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514543811"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.06.018"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10144"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280500187351"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.10.029"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2008.07.002"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.01.003"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2459"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01392.x"},{"key":"e_1_2_8_87_1","first-page":"1","article-title":"Neuromodulation, emotional feelings and affective disorders full text introduction","volume":"1","author":"Wang F","year":"2017","journal-title":"Mens Sana Monogr"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.157.1.75"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.055251"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24029"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.03.019"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.06.016"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.09.027"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.07.025"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.06.005"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00060-X"},{"key":"e_1_2_8_97_1","volume-title":"Inflammation and Immunity in Depression","author":"Baune BT","year":"2018"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.33"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000291557.62706.d3"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.03.002"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199902)41:2<276::AID-MRM10>3.0.CO;2-8"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000121805.12350.CA"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1254"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.10.001"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13090"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T03:43:33Z","timestamp":1695008613000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":104,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/apt.14594"],"URL":"https:\/\/doi.org\/10.1111\/apt.14594","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,14]]}}}