{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:32:14Z","timestamp":1759177934404,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In liver transplant recipients with hepatitis C virus recurrence, there is concern about renal safety of sofosbuvir\u2010based regimens. Changes in serum creatinine or in the estimated glomerular filtration rate (eGFR) under treatment are used to look for possible renal toxicity. However, serum creatinine and <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> are highly variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyse renal function trajectory with numerous assays of serum creatinine over a long period of time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multicentre cohort of 139 patients, the eGFR was obtained from serum creatinine using the Chronic Kidney Disease\u2013Epidemiology Collaboration (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EPI<\/jats:styled-content>) equation. Slopes of <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> were defined as a change in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> during a period divided by time. Pre\u2010treatment, on\u2010treatment and post\u2010treatment periods were 9\u00a0months, 3\u20109\u00a0months and 4.5\u00a0months. Interactions between <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> slopes and the pre\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR,<\/jats:styled-content> use of ribavirin or mycophenolate mofetil, and stage of fibrosis were addressed. On\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> slopes were separated in tertiles. Pre\u2010 and post\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> slopes were compared globally and according to tertiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The post\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> slope was significantly better than pre\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> slope (+0.18 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> \u22120.76 to +1.32) vs \u22120.11 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> \u22121.01 to +0.73) <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>\/month, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) independently of the pre\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.99), ribavirin administration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.26), mycophenolate mofetil administration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.51) and stage of fibrosis (F3 and F4 vs lower stages, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.18; F4 vs lower stages, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08; F4 Child\u2010Pugh B and C vs lower stages, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.38). Tertiles of on\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> slopes were \u22121.71 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> \u22122.54 to \u22121.48), \u22120.78 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> \u22121.03 to \u22120.36) and +0.75 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> +0.28 to +1.47) <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>\/month. Pre\u2010 and post\u2010treatment <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> slopes were not significantly different according to tertiles (respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.34, 0.08, 0.73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> varies during treatment and gives a confusing picture of the renal safety of sofosbuvir\u2010based regimens. In contrast, longitudinal assessment of the <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> shows a rising trajectory over longer time, meaning that these therapies are safe for the kidneys in our cohort of liver transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14639","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T17:53:36Z","timestamp":1523987616000},"page":"1682-1689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety of sofosbuvir\u2010based regimens after liver transplantation: longitudinal assessment of renal function in the prospective <scp>ANRS<\/scp> CO23 CUPILT study"],"prefix":"10.1111","volume":"47","author":[{"given":"R.","family":"Anty","sequence":"first","affiliation":[{"name":"Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-4344","authenticated-orcid":false,"given":"G.","family":"Favre","sequence":"additional","affiliation":[{"name":"Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Coilly","sequence":"additional","affiliation":[{"name":"Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Houssel\u2010Debry","sequence":"additional","affiliation":[{"name":"Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Duvoux","sequence":"additional","affiliation":[{"name":"Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-1951","authenticated-orcid":false,"given":"V.","family":"De Ledinghen","sequence":"additional","affiliation":[{"name":"Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Leroy","sequence":"additional","affiliation":[{"name":"Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Radenne","sequence":"additional","affiliation":[{"name":"Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kamar","sequence":"additional","affiliation":[{"name":"Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Canva","sequence":"additional","affiliation":[{"name":"Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"D'Alteroche","sequence":"additional","affiliation":[{"name":"Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Durand","sequence":"additional","affiliation":[{"name":"Clichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-5396","authenticated-orcid":false,"given":"J.","family":"Dumortier","sequence":"additional","affiliation":[{"name":"Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lebray","sequence":"additional","affiliation":[{"name":"Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Besch","sequence":"additional","affiliation":[{"name":"Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tran","sequence":"additional","affiliation":[{"name":"Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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