{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:51:56Z","timestamp":1789563116449,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Data are limited regarding the effectiveness and safety of generic velpatasvir plus sofosbuvir (VEL<\/jats:styled-content>\/SOF<\/jats:styled-content>) for hepatitis C virus (HCV<\/jats:styled-content>) in patients with or without human immunodeficiency virus (HIV<\/jats:styled-content>) coinfection.<\/jats:p><\/jats:sec>Aim<\/jats:title>To evaluate the effectiveness and safety of genericVEL<\/jats:styled-content>\/SOF<\/jats:styled-content>\u2010based therapy forHCV<\/jats:styled-content>infection in patients with or withoutHIV<\/jats:styled-content>coinfection in Taiwan.<\/jats:p><\/jats:sec>Methods<\/jats:title>Sixty\u2010nineHIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected and 159HCV<\/jats:styled-content>\u2010monoinfected patients receiving 12\u00a0weeks of genericVEL<\/jats:styled-content>\/SOF<\/jats:styled-content>with or without ribavirin (RBV<\/jats:styled-content>) forHCV<\/jats:styled-content>were prospectively enrolled. The anti\u2010viral responses and the adverse events (AE<\/jats:styled-content>s) were compared between the two groups. The characteristics potentially related to sustained virological response 12\u00a0weeks off therapy (SVR<\/jats:styled-content>12<\/jats:sub>) were analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>TheSVR<\/jats:styled-content>12<\/jats:sub>was achieved in 67HIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected patients (97.1%; 95%CI<\/jats:styled-content>: 90.0%\u201099.2%) and in 156HCV<\/jats:styled-content>\u2010monoinfected patients (98.1%; 95%CI<\/jats:styled-content>: 94.6%\u201099.4%) receivingVEL<\/jats:styled-content>\/SOF<\/jats:styled-content>\u2010based therapy, respectively. TheSVR<\/jats:styled-content>12<\/jats:sub>rates were comparable betweenHIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected andHCV<\/jats:styled-content>\u2010monoinfected patients, regardless of pre\u2010specified baseline characteristics. One hundred twenty\u2010two (53.5%) and seven (3.1%) patients had baseline resistance\u2010associated substitutions (RAS<\/jats:styled-content>s) inHCV NS<\/jats:styled-content>5A andNS<\/jats:styled-content>5B regions, but theSVR<\/jats:styled-content>12<\/jats:sub>rates were not affected by the presence or absence ofRAS<\/jats:styled-content>s. One (1.4%) and five (3.1%) patients in theHIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected andHCV<\/jats:styled-content>\u2010monoinfected groups had seriousAE<\/jats:styled-content>s. No patient died or discontinued treatment due toAE<\/jats:styled-content>s. TheeGFR<\/jats:styled-content>remained stable throughout the course of treatment inHIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected patients receiving anti\u2010retroviral therapy containing tenofovir disoproxil fumarate (TDF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>GenericVEL<\/jats:styled-content>\/SOF<\/jats:styled-content>\u2010based therapy is well\u2010tolerated and provides comparably highSVR<\/jats:styled-content>12<\/jats:sub>rates forHCV<\/jats:styled-content>infection in patients with and withoutHIV<\/jats:styled-content>coinfection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14647","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T17:56:26Z","timestamp":1523987786000},"page":"1690-1698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Generic velpatasvir plus sofosbuvir for hepatitis C virus infection in patients with or without human immunodeficiency virus coinfection"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-9707","authenticated-orcid":false,"given":"C.\u2010H.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital Douliou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-0993","authenticated-orcid":false,"given":"C.\u2010J.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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