{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:59:29Z","timestamp":1784033969035,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of direct\u2010acting anti\u2010viral (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>) therapy in patients with a history of hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We prospectively evaluated whether previously treated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> affects <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> efficacy in a large real\u2010life cohort of cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January to December 2015 all consecutive <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> mono\u2010infected patients with cirrhosis and\/or history of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> attending 10 Italian tertiary liver centres were enrolled. Baseline characteristics and response to therapy were recorded. 1927 patients were enrolled (mean age: 62.1\u00a0\u00b1\u00a010.9\u00a0years; 1.205 males). Genotype 1 was the most frequent (67.9%) followed by genotypes 3 (12.4%), 2 (11.2%) and 4 (8.6%). 88.4% and 10.9% of cases were classified Child A and B, respectively, and 14 (&lt;1%) cases were classified Child C. Ascites and hepatic encephalopathy occurred in 10.7% and 3.2% of patients, respectively. Varices were detected in 39.3% of patients. Suboptimal and optimal treatment was prescribed: 15.9% of patients received sofosbuvir\/simeprevir, 33.4% sofosbuvir\/ledipasvir, 20.2% a Viekirax\u00a0+\u00a0Exviera regimen, 15.7% sofosbuvir\/ribavirin, 9.9% sofosbuvir\/daclatasvir and 3.4% Viekirax; 1.3% of patients received an interferon\u2010based regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sustained virologic response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) rate at intention\u2010to\u2010treat analysis was 95.1%. It differed significantly across Child classes, that is, 96.3%, 86.1% and 71.4% Child A, B and C, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and across genotypes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). The <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> rate did not differ between patients with (95.0%) and those without previous <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> (95.1%). At multivariable analysis, <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> was significantly associated with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype, Child class.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This large real\u2010life study proves that the efficacy of <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> in cirrhotic patients is not impaired by successfully treated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14685","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T10:14:10Z","timestamp":1525342450000},"page":"1705-1712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["High efficacy of direct\u2010acting anti\u2010viral agents in hepatitis C virus\u2010infected cirrhotic patients with successfully treated hepatocellular carcinoma"],"prefix":"10.1111","volume":"47","author":[{"given":"M.","family":"Persico","sequence":"first","affiliation":[{"name":"Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-0172","authenticated-orcid":false,"given":"A.","family":"Aglitti","sequence":"additional","affiliation":[{"name":"Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0941-3226","authenticated-orcid":false,"given":"A.","family":"Aghemo","sequence":"additional","affiliation":[{"name":"Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rendina","sequence":"additional","affiliation":[{"name":"Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lleo","sequence":"additional","affiliation":[{"name":"Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ciancio","sequence":"additional","affiliation":[{"name":"Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-4206","authenticated-orcid":false,"given":"V.","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-7476","authenticated-orcid":false,"given":"P.","family":"Lampertico","sequence":"additional","affiliation":[{"name":"Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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