{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:41:50Z","timestamp":1782952910529,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG SFB841"],"award-info":[{"award-number":["DFG SFB841"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO306"],"award-info":[{"award-number":["KFO306"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with primary sclerosing cholangitis follow\u2010up magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) is performed by many centres, particularly for the early detection of biliary malignancies and strictures. Clinically meaningful <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010based definitions of primary sclerosing cholangitis related complications are, however, lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate how primary sclerosing cholangitis experts interpret follow\u2010up MRI\/MRCP with a focus on conclusions that may impact clinical decision\u2010making in primary sclerosing cholangitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within the International Primary Sclerosing Cholangitis Study Group, an online survey on 16 real\u2010life primary sclerosing cholangitis cases including clinical and biochemical information as well as a T2\u2010weighted liver MRI\/3D\u2010MRCP was conducted. The interpretation of images and subsequent recommendations were assessed using a multiple\u2010choice questionnaire. An inter\u2010rater reliability calculation (Fleiss\u2032 kappa) was performed and factors potentially affecting the interpretation of magnetic resonance images were analysed using generalised linear mixed\u2010effect models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four members\/associates of the International Primary Sclerosing Cholangitis Study Group (median experience in the care of primary sclerosing cholangitis patients: 14\u00a0years) completed the survey. The MRI interpretation significantly varied among the participants. The lowest agreement was found with respect to the indication to perform subsequent endoscopic retrograde cholangiopancreatography (ERCP; \u039a\u00a0=\u00a00.12, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.11\u20100.14). Elevated total bilirubin was the variable with the strongest effect on the rate of suspected dominant strictures, cholangiocarcinoma or ERCP recommendations. Liver cirrhosis did not prevent participants from recommending ERCP. Overall, the survey participants\u2032 recommendations contrasted the real\u2010life management and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In primary sclerosing cholangitis, the interpretation of follow\u2010up MRI\/3D\u2010MRCP significantly varies even among experts and seems to be primarily affected by bilirubin levels. Generally accepted MRI\u2010based definitions of primary sclerosing cholangitis\u2010related complications are urgently needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14797","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T10:29:24Z","timestamp":1525861764000},"page":"169-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Follow\u2010up magnetic resonance imaging\/3D\u2010magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-0924","authenticated-orcid":false,"given":"R.","family":"Zenouzi","sequence":"first","affiliation":[{"name":"1st Department of Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Liwinski","sequence":"additional","affiliation":[{"name":"1st Department of Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Weiler\u2010Normann","sequence":"additional","affiliation":[{"name":"1st Department of Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sebode","sequence":"additional","affiliation":[{"name":"1st Department of Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Lohse","sequence":"additional","affiliation":[{"name":"1st Department of Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Schramm","sequence":"additional","affiliation":[{"name":"1st Department of Medicine University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the International PSC Study Group (IPSCSG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26565"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.112"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.10.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/MOG.0000000000000335","article-title":"Risk of cholangiocarcinoma in patients with primary sclerosing cholangitis: diagnosis and surveillance","volume":"33","author":"Ehlken H","year":"2017","journal-title":"Curr Opin Gastroenterol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24570"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29293"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.013"},{"issue":"61","key":"e_1_2_7_11_1","first-page":"AB65","article-title":"Dominant stricutres in primary sclerosing cholangitis: a multi\u2010center survey of clinical perceptions and practices","volume":"83","author":"Tabibian JH","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000055"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.06.052"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13354"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12581"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.05.035"},{"key":"e_1_2_7_17_1","article-title":"Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis","author":"Ali AH","year":"2017","journal-title":"Hepatology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23294"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301748"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001022"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176297"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-107029"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00251-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283554bbf"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.14797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.14797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:52:51Z","timestamp":1694339571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.14797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,9]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/apt.14797"],"URL":"https:\/\/doi.org\/10.1111\/apt.14797","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,9]]},"assertion":[{"value":"2018-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}