{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:52:41Z","timestamp":1787165561626,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T00:00:00Z","timestamp":1527638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Science Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary sclerosing cholangitis is a progressive liver disease with a remarkably variable course. Biomarkers of disease activity or prognostic models predicting outcome at an individual level are currently not established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the prognostic utility of four biomarkers of basement membrane and interstitial extracellular matrix remodeling in patients with primary sclerosing cholangitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum samples were available from 138 large\u2010duct primary sclerosing cholangitis patients (of which 102 [74%] with IBD) recruited 2008\u20102012 and 52 ulcerative colitis patients (controls). The median follow\u2010up time was 2.2 (range 0\u20104.3) years. Specific biomarkers of type\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      and V collagen formation (\n                      <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>\n                      \u2010C3 and\n                      <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>\n                      \u2010C5, respectively) and type\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      collagen degradation (C3M and C4M, respectively) were assessed. The Enhanced Liver Fibrosis test, including procollagen type III N\u2010terminal peptide, tissue inhibitor of metalloproteinase\u20101 and hyaluronic acid was assessed for comparison.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All markers were elevated in primary sclerosing cholangitis compared to ulcerative colitis patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                      <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>\n                      \u2010C3 showed the largest difference between the two groups with a threefold increase in primary sclerosing cholangitis compared to ulcerative colitis patients. Patients with high baseline serum levels of all markers, except C3M, had shorter survival compared to patients with low baseline serum levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Combining\n                      <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>\n                      \u2010C3 and\n                      <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>\n                      \u2010C5 the odds ratio for predicting transplant\u2010free survival was 47 compared to the Enhanced Liver Fibrosis test's odds ratio of 11.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Extracellular matrix remodeling is elevated in primary sclerosing cholangitis patients compared to ulcerative colitis patients. Furthermore, the interstitial matrix marker\n                      <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>\n                      \u2010C3 was identified as a potent prognostic marker and an independent predictor of transplant\u2010free survival in primary sclerosing cholangitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.14806","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:15:07Z","timestamp":1527725707000},"page":"179-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Serological markers of extracellular matrix remodeling predict transplant\u2010free survival in primary sclerosing cholangitis"],"prefix":"10.1111","volume":"48","author":[{"given":"M. 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