{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:27:44Z","timestamp":1788582464977,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373644"],"award-info":[{"award-number":["81373644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473777"],"award-info":[{"award-number":["81473777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774321"],"award-info":[{"award-number":["81774321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Tong\u2010Xie\u2010Yao\u2010Fang (\n TXYF<\/jats:styled-content>\n ) is a Chinese herbal formula for treating chronic diarrhoea accompanied by abdominal pain. The results were inconsistent in previous trials examining its effect.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To study the efficacy of\n TXYF<\/jats:styled-content>\n granules for treating diarrhoea\u2010predominant irritable bowel syndrome (\n IBS<\/jats:styled-content>\n \u2010D).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed a double\u2010blind, placebo\u2010controlled randomised trial and enrolled 160 participants with\n IBS<\/jats:styled-content>\n \u2010D. The participants had\n VAS<\/jats:styled-content>\n scores \u22653 cm in\n IBS<\/jats:styled-content>\n \u2010D global symptoms and \u22652 days in a week with abdominal pain and loose stools (Bristol score 5, 6 or 7). They were randomly assigned to received\n TXYF<\/jats:styled-content>\n or placebo during a treatment period of 4 weeks, and they were followed up for 8 weeks after treatment. The primary outcome was adequate relief of\n IBS<\/jats:styled-content>\n \u2010D global symptoms for at least 2 of 4 weeks during weeks 1\u20104. Secondary outcomes included mean weekly\n VAS<\/jats:styled-content>\n scores of\n IBS<\/jats:styled-content>\n \u2010D major symptoms, mean weekly stool frequency, mean weekly Bristol score, and adverse events.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 155 of 160 patients completed the trial. We found a significantly higher rate of adequate relief of global symptoms in\n TXFY<\/jats:styled-content>\n group during weeks 1 to 4 (57.5% vs 37.5%, \u03c7\n 2<\/jats:sup>\n = 5.6391,\n P<\/jats:italic>\n = 0.017); logistic regression analysis showed a similar result (\n OR<\/jats:styled-content>\n 2.2, 95%\n CI<\/jats:styled-content>\n 1.2\u20104.4,\n P<\/jats:italic>\n = 0.016). Most of the secondary outcomes showed superiority of\n TXYF<\/jats:styled-content>\n over placebo in weekly assessment from week 3 to week 7. The adverse event rate was low in both groups (3.8% vs 3.8%,\n P<\/jats:italic>\n = 1.000).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n During a 4 week trial, TXFY granules were superior to placebo in controlling symptoms of IBS\u2010D.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.14817","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T08:45:40Z","timestamp":1527842740000},"page":"160-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Randomised clinical trial: Tong\u2010Xie\u2010Yao\u2010Fang granules versus placebo for patients with diarrhoea\u2010predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"48","author":[{"given":"M.","family":"Chen","sequence":"first","affiliation":[{"name":"Clinical Medicine College\/Teaching hospital Chengdu University of Traditional Chinese Medicine Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010C.","family":"Tang","sequence":"additional","affiliation":[{"name":"Clinical Medicine College\/Teaching hospital Chengdu University of Traditional Chinese Medicine Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Colorectal Department Luzhou People's Hospital Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Shui","sequence":"additional","affiliation":[{"name":"Clinical Medicine College\/Teaching hospital Chengdu University of Traditional Chinese Medicine Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010H.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Clinical Medicine College\/Teaching hospital Chengdu University of Traditional Chinese Medicine Chengdu Sichuan 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