{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:15:27Z","timestamp":1773551727313,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,8]],"date-time":"2018-07-08T00:00:00Z","timestamp":1531008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["522\u20102A09\u2010195"],"award-info":[{"award-number":["522\u20102A09\u2010195"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK083256"],"award-info":[{"award-number":["T32 DK083256"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Earlier studies have produced highly varying risk estimates for the prevalence of coeliac disease (CD) in osteoporosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the prevalence of CD among individuals with osteoporosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review of articles published in PubMed, Medline or EMBASE through May 2017 to identify studies looking at prevalence of CD in patients with osteoporosis. Search terms included \u201ccoeliac disease\u201d combined with \u201cfractures\u201d, \u201cbone disease\u201d, \u201cbone density\u201d, \u201cdensitometry\u201d, \u201costeoporos*\u201d, \u201costeomal*\u201d, \u201costeodys\u201d or \u201cdexa\u201d or \u201cdxa\u201d or \u201cskelet\u201d. Non\u2010English papers with English\u2010language abstracts were included. We used fixed\u2010effects inverse variance\u2010weighted models, and tested heterogeneity through subgroup analysis as well as through meta\u2010regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified eight relevant studies, comprising data from 3188 individuals with osteoporosis. Of these, 59 individuals (1.9%) had CD. A weighted pooled analysis demonstrated biopsy\u2010confirmed CD in 1.6% (95% CI\u00a0=\u00a01.1%\u20102.0%) of individuals with osteoporosis. The heterogeneity was moderate (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a040.1%), and influenced by the underlying CD prevalence in the general population. After adding four studies (n\u00a0=\u00a0814) with CD defined as positive tissue transglutaminase or endomysial antibodies, the pooled prevalence was comparable (1.6%; 95% CI\u00a0=\u00a01.2%\u20102.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>About 1 in 62 individuals with osteoporosis, or 1.6%, have biopsy\u2010verified CD. This prevalence is comparable to that in the general population. These findings argue against routinely screening patients with osteoporosis for CD, which is contrary to current guideline recommendations. Additional studies are needed to determine the true utility of such screening programs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14911","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T06:38:41Z","timestamp":1531118321000},"page":"590-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Systematic review with meta\u2010analysis: the prevalence of coeliac disease in patients with osteoporosis"],"prefix":"10.1111","volume":"48","author":[{"given":"M.","family":"Laszkowska","sequence":"first","affiliation":[{"name":"Department of Medicine Celiac Disease Center Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mahadev","sequence":"additional","affiliation":[{"name":"Department of Medicine Celiac Disease Center Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala Clinical Research Center Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lebwohl","sequence":"additional","affiliation":[{"name":"Department of Medicine Celiac Disease Center Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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